黏膜NK/T和成熟T细胞淋巴瘤MMP9表达及其与EBV感染的关系  

Expressions of matrix metalloproteinase 9 in mucosal natural killer/T cell and mature T cell lymphomas and its relation to Epstein-Barr virus infection

作　　者：冯智英[1] 莫祥兰[1] 邵春奎[1] 苏组兰[1] 

机构地区：[1]中山大学附属第三医院病理科,广东广州510630

出　　处：《南方医科大学学报》2007年第9期1338-1340,共3页Journal of Southern Medical University

基　　金：国家自然科学基金(39870328)~~

摘　　要：目的探讨MMP9在黏膜NK/T和成熟T细胞淋巴瘤的表达及其与EBV感染的关系。方法用免疫组化SP法和原位杂交法检测59例黏膜NK/T以及成熟T细胞淋巴瘤MMP9和EBER表达情况,统计MMP9表达与EBV感染的关系。结果黏膜NK/T和成熟T细胞淋巴瘤MMP9和EBER阳性率分别为83.05%和72.88%,EBER阳性率与组织学类型有关(P<0.01);MMP9和EBER表达与临床分期和生存期均无显著性关系(P>0.05),MMP9表达与EBV感染无明显相关性(P>0.05)。结论黏膜NK/T和成熟T细胞淋巴瘤发生与EBV感染密切相关,它可能通过间接上调MMP9等癌基因的表达而促进肿瘤的发生和发展。防治EBV感染有助于预防淋巴瘤的发生和发展。Objective To investigate the expression of matrix metaltoproteinase 9 （MMP9） in mucosal natural kitler/T cell and mature T cell lymphomas and its relation to Epstein-Barr virus （EBV） infection. Methods The expression of MMP9 and EBV-encoded RNA （EBER） were detected by immunohistochemistry and in situ hybridization in 59 cases of mucosal natural killer/T cell and mature T cell lymphomas. Results The positivity rates of MMP9 and EBERs were 83.05% and 72.88% respectively. The positivity rate of EBERs was correlated with histopathological subtype （P〈0.05）, but not with clinical stage, vascular invasion or the patients＇ survival time （P〉0.05）. The expression level of MMP9 was not correlated with the clinical stage, vascular invasion or survival time （P〉0.05）. No significant correlation was found between MMP9 expression and EBV infection. Conclusion EBV may play an important role in the development ofmucosal natural killer/T cell and mature T cell lymphomas and promote disease progression by up-regulating MMP9 expression indirectly. Elimination of EBV infection may be helpful to prevent the development oflymphoma.

关 键 词：黏膜 杀伤细胞 天然 T细胞 淋巴瘤 基质金属蛋白酶9 疱疹病毒4型 人 原位杂交法 

分 类 号：R733.1[医药卫生—肿瘤]