胆石病与胰岛素抵抗相关指标关系的临床研究  

A Clinical Study of the Association of Cholelithiasis with Factors Related to Insulin Resistance

作　　者：梁晓强[1] 方邦江[1] 裴新军[1] 张静喆[1] 

机构地区：[1]上海中医药大学附属龙华医院胆道外科,上海200032

出　　处：《辽宁中医杂志》2007年第9期1244-1246,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：上海市重点学科课题(T0304);上海市卫生系统百人计划课题(03HBR-29);上海市科委课题(03JC14066)

摘　　要：目的:探讨胰岛素抵抗相关指标与胆石病发病之间的关系。方法:选择26例单纯胆结石患者和30例健康对照者作为两组研究对象。采用清晨肘前静脉采血测定空腹血糖、空腹胰岛素水平和空腹C肽,并计算胰岛素敏感指数。结果:两组对象除胆石病外其他基本情况无显著差异(P>0.05)。C肽在胆结石组与对照组之间无显著性差异(P>0.05)。胆石病组的空腹血糖、胰岛素水平高于对照组,而胰岛素敏感系数低于对照组,两组之间差异有统计学意义(P<0.05)。结论:胆石病患者存在一定程度的胰岛素抵抗,胆石病的发病学机理可能涉及胰岛素抵抗。Objective： To study the relationship between cholelithiasis and some factors correlated with insulin resistance. Method： Two groups of people were selected including 26 patients with cholellthiasis and 30 healthy volunteers as control. Fasting plasma glucose （FPC;）, insulin （FinS） and C -peptide （FCP） were tested and insulin sensitivity index （ISI） was counted for comparison between both groups. Results ： There existed well comparability of clinical characteristics between two groups （ P 〉 0. 05）. No significant difference of FCP was found between both groups （ P 〉 0.05 ）. FPG and Fins of patients were significantly higher than that of control （ P 〈 0. 05 ）, and ISI of patients was significantly lower than that of control （ P 〈 0. 05 ）. Conclusion： There probably exists insulin resistance in some degree in patients with cholelithiasis, the pathogenesis of cholelithiasis maybe refer to insulin resistance.

关 键 词：胆石病 胰岛素抵抗 空腹血糖 空腹胰岛素 C肽 胰岛素敏感指数 

分 类 号：R575.62[医药卫生—消化系统]