消化道癌与正常人神经内分泌、免疫功能及社会心理因素的研究  

Control study on neuroendocrinologic and immunologic function,and sociopsychologic factors in patients with digestive tract carcinoma and normal subjects.

作　　者：张理义 金国元[1,2,3] 李斌 高柏良[1,2,3] 崔庶 孙芳卿 薛蕴庄 

机构地区：[1]江苏省常州全军精神卫生中心 [2]常州第一人民医院 [3]常州卫生学校

出　　处：《中国行为医学科学》1997年第1期42-46,共5页Chinese Journal of Behavioral Medical Science

基　　金：南京军区中青年科研基金南京军区中青年科研基金

摘　　要：研究消化道癌与神经内分泌、免疫功能、个性及社会心理因素的关系。方法连续入院的消化道癌患者与健康人按１：１配对，对皮质醇（Ｆ）、生长激素（ＧＨ）、Ｔ３、Ｔ４、免疫功能、社会心理问题等进行了分析。结果（１）消化道癌患者有心理压力大、人际关系紧张、睡眠障碍及社会支持缺乏；（２）其血清Ｆ、ＧＨ及Ｔ３明显升高，而免疫功能下降；（３）消化道癌的个性有精神质（Ｐ）、神经质（Ｎ）、内向及掩饰性倾向。结论消化道癌患者有明显的神经内分泌、免疫功能的异常及社会心理问题：影响消化道癌免疫功能的因素与生物、心理及社会综合因素有关。Objective To evaluate the neuroendocrinologic function,immunologic function, personality and sociopsychologic factors on the patients with digestive tract carcinoma.Methods 150 digestive tract carcinoma patients matching with equal normal objects as control were joined in this study. Cortisol, GH, T 3, T 4,immunological function and sociopsychologic problems were analyzed.Results (1) The results revealed the patients had more heavy psychological stress, more tense interpersonal relationship, sleep disorder and also lacked of social support. (2) Serum contents of cortisol、 GH and T 3 in the patients increased prominently while the immunnologic functions reduced. (3) The personality of the patients were prone to psychotism, neurotism, introversion and lying. Conclusios The patients with digestive carcinoma have more disturbances including with neuroendocrine function、 immunological function and sociopsychological problem. The factors influencing the immunologic function on the patients with digestive carcinoma were related to biological,psychological and sociological aspect, synthetically.

关 键 词：消化道癌 免疫功能 神经内分泌 社会心理因素 

分 类 号：R735.02[医药卫生—肿瘤]