抗病毒口服液中挥发油羟丙基-β-环糊精包合物的制备研究  

Study on the Preparation of HP-β-cyclodextrin Inclusion of Volatile Oils in Anti-virus Oral Solution

作　　者：邓丽明[1] 林华庆[1] 邓红[1] 陈航[2] 

机构地区：[1]广东药学院药物研究所,广州510006 [2]江苏省药品检验所,南京210008

出　　处：《中药新药与临床药理》2007年第5期402-405,共4页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的研究羟丙基-β-环糊精(HP-β-CD)包合抗病毒口服液挥发油的最佳工艺条件。方法以包合物收得率、挥发油包合率为指标,比较超声波法、饱和水溶液法、研磨法的包合效果,确定最优包合方法;再采用正交实验法,以挥发油与HP-β-CD比例、包合温度、包合时间为因素,每因素选择3水平,优选包合条件,同时采用薄层色谱法、差示扫描量热法和紫外分光光度法验证包合物。结果优选出最佳工艺为:挥发油与HP-β-CD比例为1∶12,包合温度45℃,包合时间为3h,挥发油的包合率为66.71%,包合物的收得率为90.07%。结论按优选工艺条件,挥发油与HP-β-CD形成稳定的包合物,且挥发油利用率较高。Objective To optimize the HP - β - cyclodextrin （ HP- β - CD） inclusion process condition for volatile oils from Anti - virus Oral Solution. Methods The process conditions were screened by determining the inclusion rate of volatile oils and the yield of inclusion compound, and by comparing the inclusion effect of supersonic method, saturated water solution method and grinding method. The optimum condition was investigated by the orthogonal test. The inclusion compound was identified by TLC, differential scanning calorimetry（DSC） and ultraviolet spectrophotometry （UV）. Results The optimum preparation conditions for inclusion were established as follows： the proportion of volatile oils and HP - β - cyclodextrin was 1 ： 12, the inclusion temperature was at 45 ℃ and the inclusion time was 3 hours. The inclusion rate of volatile oils was 66. 71% , and the yield of inclusion compound was 90, 07 %. Conclusion The complex prepared under the optimized condition is stable and has a highest inclusion rate.

关 键 词：抗病毒口服液 挥发油 羟丙基-Β-环糊精包合物 正交试验 

分 类 号：R284.2[医药卫生—中药学]