Ras相关区域家族1A基因甲基化与恶性肿瘤关系的研究进展  

Research progress in Ras association domain family 1A gene hypermethylation and cancer

作　　者：于正洪[1] 王玉才[1] 马驰原[2] 苏全胜[1] 

机构地区：[1]南京军区南京总医院肿瘤内科干部病区,江苏南京210002 [2]南京军区南京总医院博士后科研工作站,江苏南京210002

出　　处：《医学研究生学报》2007年第9期985-989,共5页Journal of Medical Postgraduates

基　　金：江苏省六大人才高峰重点基金资助项目(批准号:2005A2);南京军区南京总医院科研基金资助项目(批准号:2005018)

摘　　要：Ras相关区域家族1A(RASSF1A)基因是新近发现的新型候选抑癌基因,其正常表达能抑制肿瘤的发生。启动子区域CpG岛异常甲基化可以导致其失活,并在肿瘤的发生、发展中起着重要作用。RASSF1A的甲基化状态检测具有重要的临床意义,有望为肿瘤的早期诊断提供新的思路,而逆转RASSF1A的甲基化则可能成为肿瘤治疗的新方向。Ras association domain family 1A （RASSF1A） gene is a novel candidate tumor suppressor gene and its normal expression can prohibit carcinogenesis. The aberrant methylation of CpG islands could lead to the inactivation of RASSF1A, playing an important role in the genesis and development of cancer. RASSF1A methylation status examination is clinically significant, and could serve as a new technique for the early diagnosis of cancer, while reversing the methylation of RASSF1A is a promising idea for cancer therapy.

关 键 词：RAS相关区域家族1A 抑癌基因 肿瘤 甲基化 

分 类 号：R730.231[医药卫生—肿瘤]