云芝糖肽对肿瘤浸润淋巴细胞功能的促进作用  

Polysaccharidical peptides augmented the functions of tumour infiltrating lymphocytes

作　　者：周旻[1] 简志瀚[2] 李树浓 

机构地区：[1]中山医科大学病理生理教研室,广州510089 [2]广州市肿瘤医院,510095

出　　处：《中国病理生理杂志》1997年第2期170-172,共3页Chinese Journal of Pathophysiology

摘　　要：本文研究了云芝糖肽(PSP)在体外对肿瘤浸润淋巴细胞(TILs)功能的影响,发现PSP在37～1200μg/ml浓度内可促进TILs的增殖反应,其促增殖作用与PSP浓度存在一定的依赖关系。联合使用PSP和白细胞介素2(IL-2)可提高TILs的杀伤功能,并可减少IL-2的使用剂量。提示:在肿瘤的生物治疗中,使用PSP可提高TILs的疗效,并可减轻因使用大剂量IL-2所致的副作用。The effects of polysaccharidical peptides (PSP) on the functions of tumour infiltrating lymphocytes (TILs) in vitro was explored. The results showed that PSP, at the concentration of 37-1200μg/ml, promoted the proliferation of TILs in dose-related manner. Combination of PSP with interleukin-2 (IL-2) enhanced the cytotoxicity of TILs and reduced the dose of IL-2 used for activating TILs. The results suggested that PSP could augment the proliferation and cytotoxicity of TILs in vitro.

关 键 词：肿瘤浸润 淋巴细胞 云芝糖肽 

分 类 号：R730.53[医药卫生—肿瘤]