胰岛素样生长因子Ⅰ启动子区域基因多态性与新生儿血清IGF-Ⅰ水平的关系  被引量:9

The association between polymorphism in the promoter region of insulin-like growth factorⅠ gene and the serum level of IGF-Ⅰ in neonates

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作  者:张娟[1] 张淑丽[1] 王朝虹[1] 李松[1] 王新利[1] 

机构地区:[1]北京大学第三医院儿科,100083

出  处:《中国新生儿科杂志》2007年第5期264-267,共4页Chinese Journal of Neonatology

摘  要:目的检测新生儿胰岛素样生长因子Ⅰ(IGF-Ⅰ)启动子区域(CA)n重复标记位点的基因多态性,及新生儿血清IGF-Ⅰ浓度,探讨基因多态性与血清IGF-Ⅰ浓度的关系,分析相关的遗传背景。方法202名健康新生儿根据胎龄分为早产(111名)和足月(91名)两组,记录出生体重、身长;于生后第3~5天取血,酶联免疫法检测血清IGF-Ⅰ、生长激素(GH)浓度;提取DNA,分析IGF-Ⅰ启动子区域基因多态性。结果在202名新生儿中,发现7种不同的等位基因及20种基因型。7种等位基因频率分别为7.92%、14.60%、43.56%、7.43%、21.78%、3.96%、1.10%,其中携带190等位基因的早产新生儿的血清IGF-Ⅰ水平及出生体重相对较低。未发现基因多态性与出生身长相关。结论IGF-Ⅰ基因启动子区域190等位基因可能与早产新生儿出生体重及血清IGF-Ⅰ浓度相关。本研究提示基因可能影响出生前生长和血清IGF-Ⅰ水平的关系。Objective To study the related genetic backgrounds with the analyze polymorphism in the promoter region of Insulin-Like Growth Factor Ⅰ ( IGF- Ⅰ ) gene and the serum level of IGF-Ⅰ in neo- nates. Methods Two hundred and two healthy neonates included in this study. They were divided into preterm group (111 infants) and term group (91 infants). Their birth weight and birth length were recorded. The serum IGF-Ⅰ level was tested and DNA was extracted for PCR study to analyze polymorphism of CA repeated marker in the promoter region of IGF-Ⅰ gene in both groups. Results There were 7 different kinds of alleles and 20 genotypes identified in these 202 neonates. The incidence of 7 different alleles were 7.92%, 14.60% ,43.56% ,7.43% ,21.78% ,3.96%, 1.10% respectively. The serum levels of IGF- I were lower in preterm neonates who carries 190 allele and their birth weight were found lower (P 〈 0. 05). There was no relation between polymorphism and birth length. Conclusions The polymorphism of IGF-Ⅰ gene affects the birth weight and serum level of IGF-Ⅰ in early life of neonates. This study suggests its genetic role on prenatal growth and serum level of IGF-Ⅰ in neonates.

关 键 词:胰岛素样生长因子Ⅰ 基因 婴儿 新生 

分 类 号:R722.1[医药卫生—儿科]

 

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