肝素酶在唾液腺腺样囊性癌中的表达及其意义  

Expression of heparanase in adenoid cystic carcinoma of salivary glands

作　　者：万宏坤[1] 陈曹萍 宋晓萌[1] 张嘉佳[1] 吴煜农[1] 

机构地区：[1]南京医科大学口腔医学研究所,南京医科大学附属口腔医学院口腔颌面外科,南京210029 [2]如东县人民医院口腔科,如东226400

出　　处：《口腔医学》2007年第8期432-434,共3页Stomatology

摘　　要：目的探讨肝素酶在唾液腺腺样囊性癌中的表达及与肿瘤的临床病理及生物学行为的关系。方法采用免疫组化S-P法检测35例唾液腺腺样囊性癌和正常腺体中肝素酶的表达。结果35例腺样囊性癌标本中肝素酶表达阳性为32例,阳性率为91.4%。肝素酶的表达主要位于胞膜及胞质。在实性型以及神经侵袭的标本中表达增强(P<0.05),但其表达强度与性别、年龄无关。肝素酶在正常腺体内没有表达。结论肝素酶的表达与腺样囊性癌的侵袭以及预后关系密切。Objective To reveal the relationship between expression of heparannse and tumor pathology and biologic behavior of adenoid cystic carcinoma（ACC）of salivary glands. Methods The expressions of heparanase were analyzed in 35 cases of adenoid cystic carcinoma and 15 normal salivary glands by immunohistochemistry. Results Among the 35 ACCs, 32 were positive in heparannse, with a positive rate 91.4%. There was no expression of heparanase in normal glands. The expression of heparanase positively correlated with perineural invasion and pathologic subtype. Conclusions The expression of heparanase in ACC of salivary glands might be closely related with the invasion and prognosis.

关 键 词：腺样囊性癌 肝素酶 免疫组化 预后 

分 类 号：R739.87[医药卫生—肿瘤]