泌尿系肿瘤患者血清中肿瘤坏死因子的水平及意义  

Serum TNF level in patients with urological malignancy

作　　者：王立忠[1] 刘润华[1] 严友农 夏松青 赵长林[1] 郝毅松[1] 姜力 

机构地区：[1]沈阳医学院附属中心医院

出　　处：《中华泌尿外科杂志》1997年第3期178-180,共3页Chinese Journal of Urology

摘　　要：为探讨泌尿系肿瘤患者血清中肿瘤坏死因子（ＴＮＦ）的水平及意义，采用生物活性法对５０例泌尿系肿瘤患者血清中ＴＮＦ水平进行了测定。结果：肾癌、输尿管癌、前列腺肉瘤、睾丸精原细胞瘤和胚胎癌患者血清ＴＮＦ水平高于正常人，而膀胱癌、肾盂癌与正常人无明显差异，同时发现肾癌患者血清ＴＮＦ水平与肿瘤直径及分期相关。结果提示ＴＮＦ可能参与了肾癌的发生发展，并可成为判定肾癌发展状况及预后的临床指标，而ＴＮＦ与膀胱癌关系不密切。Serum TNF level was assayed by means of biological activity method in 50 cases of urological malignancy and was found to be elevated in patients with renal carcinoma,ureteral carcinoma,prostatic sarcoma,testicular seminoma and embryonic carcinoma.No significant change of serum TNF was noted in bladder and renal pelvis malignancy.In patients with renal cancer,serum TNF level was correlated to the tumor size and clinical stage.It was suggested that TNF might involve in the carcinogenesis and progression of renal carcinoma and might serve as a parameter for prognosis but TNF has nothing to do with bladder cancer.

关 键 词：泌尿系肿瘤 肿瘤坏死因子 血清 生物活性法 

分 类 号：R737.04[医药卫生—肿瘤] R730.43[医药卫生—临床医学]