硒多糖与亚硒酸钠的抗突变性研究  

The Antimutagenic Effects of Selenium Polysaccharide and Sodium Selenite

作　　者：王新刚[1] 邬惠琼[1] 柴莲花[1] 

机构地区：[1]同济医科大学公共卫生学院环境毒理学研究室,武汉430030

出　　处：《同济医科大学学报》1997年第2期89-91,共3页Acta Universitatis Medicinae Tongji

基　　金：国家自然科学基金!39170660

摘　　要：采用Ames试验方法，对硒多糖和亚硒酸钠的抗突变作用进行了研究。试验结果：硒多糖和亚硒酸钠在以硒浓度为0．0336～105μg／皿时，对道诺霉素致突变性的抑制率分别为27．0％～96．3％和20．1％～90．0％；对间接致突物环磷酰胺的抑制率分别为15．4％～51．1％和17.0％～47.6％。硒多糖对叠氮钠致突变的抑制率为1.7％～15．5％。表明硒多糖和亚硒酸钠对道诺霉素致突变性有明显的抑制作用，对环磷酰胺的致突变性有一定抑制作用。而硒多糖对叠氮钠致突变性的抑制作用不明显。The antimutagenic effects of selenium polysaccharide and sodium selenite were investigated with the Ames test. It was shown that, at the dosage of 0.0336-105 μg Se/dish, the mutations induced by a potent mutagen daunomycin were inhibited significantly for 27.0 %-96. 3% and 20. 1%-90. 0% by selenium polysaccharide and sodium selenite, respectively; and the mutations induced by the indirect mutagen cyclophosphamide were inhibited obviously by the two agents for 15. 4 %-51. 1 % and 17. 0 %-47. 6 %.The mutagenesis of sodium azide was suppressed by selenium polysaccharide for 1. 7 % -15. 5 %.

关 键 词：硒多糖 亚硒酸钠 AMES试验 抗突变性 

分 类 号：R591.101[医药卫生—内科学] R977.5[医药卫生—临床医学]