微型染色体维持蛋白2在结肠癌中表达的研究  

Expression of Minichromosome Maintenance Proteins 2 and its Significance in Colonic Cancer

作　　者：尹嵘[1] 

机构地区：[1]上海市黄浦区中心医院外科,200002

出　　处：《实用全科医学》2007年第10期876-877,F0003,共3页Applied Journal Of General Practice

摘　　要：目的研究MCM2在结肠癌中的表达及其与临床病理特征之间的关系。方法采用免疫组化染色的方法,分别检测MCM2在23例结肠正常组织、69例结肠癌组织中的表达,计算其标记指数,分析MCM2在结肠正常组织和癌中的表达与其临床病理特征。结果69例结肠癌标本均表达MCM2,与正常组织之间的MCM2标记指数差异有统计学意义(P<0.001)。同时显示MCM2表达与结肠癌患者性别、肿块大小、病理学类型、Dukes分期、有无淋巴结转移和远处转移无关,而与结肠癌的分化程度相关。结论MCM2可能是结肠癌新的增值标记物,根据MCM2染色的组织结构差异和标记指数能比较准确区分结肠正常粘膜组织和癌组织。MCM2表达与结肠癌的分级显著相关,可以提示结肠癌的恶性程度。Objective To investigate the expression of minichromosome maintenance proteins 2 （ MCM2 ） in colonic cancer and assess the relationship between MCM2 expression and clinicopathological characteristics of colonic cancer, Methods We examined the immunohistochemical staining of MCM2 in colonic normal mucosa（ n = 23 ） and cancer（ n = 69 ） , and quantified MCM2 expression by calculating a labeling index（LI）, The pattern and LI of MCM2 expression in normal mucosa and cancer were compared, and an analysis of the association between MCM2 expression and traditional clinicopathological characteristics of colonic cancer was also carried out. Results MCM2 was expressed in all 69 colonic cancer, The differences between normal mucosa and cancer were of statistical significance（ P 〈0.001 ）, There was no statistical significance between the LI of MCM2 and some clinicopathological characteristics such as sex, dimension, histopathology, Dukes stage,lymph node metastases and distant metastases, A significant association was also demonstrated between MCM2 LI and the grade of colonic caner, Conclusions MCM2 may serve as a novel proliferation marker in colonic cancer, It is feasible to discriminate between normal tissue and cancer and can predict the degree of differentiation in colonic cancer

关 键 词：MCM2 结肠癌 表达 

分 类 号：R735.35[医药卫生—肿瘤]