一种改进的由氨基酸酯制备手性氨基醇的新方法  

An Improved Procedure for Preparing Chiral Aminoalcohols from Aminoacid Esters

作　　者：甘春芳[1] 冯瑞[1] 范建春[1] 崔建国[1] 

机构地区：[1]广西师范学院化学系,广西南宁530001

出　　处：《化学世界》2007年第9期538-540,548,552,共5页Chemical World

基　　金：广西科学基金(桂科基057554)

摘　　要：采用NaBH4/CeCl3作为还原体系,在无水甲醇溶剂中,将氨基酸甲酯还原为相应的手性氨基醇。以L-苯丙氨酸甲酯还原制备L-苯丙氨醇的反应为研究对象,考察了催化剂用量、反应温度及时间诸因素对产品收率的影响。结果表明:在n(L-苯丙氨酸甲酯)∶n(CeCl3)=1∶2、反应温度30℃、反应时间2 h的优化条件下,L-苯丙氨醇收率为90.3%。本法有操作简便,收率高等优点,该反应为制备手性氨基醇提供了一种新的有用的合成方法。Aminoalcohols were prepared by the reduction of amino acid esters with NaBH4/CeCl3 as the reducing agent in anhydrous CH3OH, The factors affecting the synthesis, including temperature, amount of catalyst and reaction time, were investigated taking the reduction of methyl 3-phenylalaninate as an example. The optimum conditions were as follows： molar ratio of L-methyl phenylalaninate to CeCl3, 1：2; reaction temperature, 30 ℃; and reaction time, 2 h. The yield of 3-phenyl-2-amino-1-propanol reached 90.3 %. The method has the advantages of simple operation and higher yield. The reaction provides a useful method for the preparation of chiral aminoalcohols.

关 键 词：氨基酸 氨基醇 还原:NaBH4/CeCl3 

分 类 号：O621.25[理学—有机化学]