E—cadherin在肝癌组织中的表达及其临床意义  

Expression of E - cadherin in hepatocarcinoma and its clinical significance

作　　者：刘新江[1] 李晓勇[1] 陈艳军[1] 周百中[1] 

机构地区：[1]郑州大学第五附属医院普外科,郑州450052

出　　处：《中原医刊》2007年第16期23-24,共2页Central Plains Medical Journal

摘　　要：目的了解肿瘤抑制基因E-cadherin在肝癌组织中的表达及其临床意义。方法应用免疫组织化学SP法检测肝细胞癌组织120例,其中临床Ⅰ-Ⅱ期60例,Ⅲ-Ⅳ期60例;30例正常肝组织作为对照组。结果正常肝组织E-cadherin的阳性表达率为100%（30/30）,而肿瘤组织的阳性率为45%（54/120）,二者之间差异有统计学意义。但各临床分期之间差异无统计学意义。结论E-cadherin作为肿瘤抑制基因在肿瘤的发生、发展中可能起重要作用,能为临床上肝癌的早期诊断及病理分期提供一定的依据。Objective To investigate the expression of E -cadberin and its clinical significance in hepatocarcinoma. Methods One hundred and twenty hepatocarcinom samples were determined by immunohistochemical staining（ Streptavidin Peroxidase method） in paraffin - embeded specimens. It included clinical stage Ⅰ - Ⅱ 60 samples, stage Ⅲ- Ⅳ 60 samples. Results The postive rate of E - cadhcrin expression in nomal liver tissue and hepatocarcinoma were 100% （30/30）,45% （54/120）, respetively. It had significant difference between normal tissue and hepatocarcinoma,but no statistically significant difference was found between clinical stage Ⅰ - Ⅱ and clinical stage Ⅲ- Ⅳ（ P 〉 0.05 ）. Conclusion E -cadherin as a suppressor, may play an important role in carcinogenesis, and progression. It may be useful in classifiing hepatocarcinomag pathological type,diagnosis and prognosis of hepatocarcinoma.

关 键 词：上皮型钙粘附素 免疫组织化学 肝癌 

分 类 号：R735[医药卫生—肿瘤]