放化疗引起的口腔黏膜炎的病理基础和诊断概况  

Pathological Basis and Diagnostic Condition of Oral Mucositis Resulting From Radiotherapy

作　　者：张文陆[1] 宇长青[1] 王言[1] 

机构地区：[1]辽宁医学院附属第一医院肿瘤科,辽宁锦州121001

出　　处：《医学综述》2007年第18期1388-1390,共3页Medical Recapitulate

摘　　要：放化疗引起的口腔黏膜炎直接损伤机制为抗肿瘤药物或射线所引起的直接黏膜损伤,间接损伤机制中与口腔黏膜损伤是由于炎性介质的释放,同时放疗所引起的中性粒细胞减少有关;化疗所引起的黏膜炎与所用化疗药物、治疗持续的时间和剂量强度有关,放疗所引起的黏膜炎的程度和持续时间与放射源、照射累积剂量、剂量强度、照射黏膜的体积、吸烟饮酒习惯以及其他因素如口腔干燥或口腔感染有关;病理生理分为以下几个阶段:起始阶段,炎症/血管阶段,上皮阶段,溃疡/细菌阶段,痊愈阶段。口腔黏膜炎的毒性分级标准通常根据世界卫生组织的分级标准。　Injury mechanism of oral mucositis resulting from radiotherapy and chemotherapy includes direct and indirect,the former are direct mucosal injury resulting from anti-tumor drugs or ray,the later results from inflammatory releasing besides neutropenia induced by radiotherapy.Mucositis resulting from chemotherapy is related to the used drug,dose intensity,volume having radiation,habites of drinking and smoking and the other factors including xerostomia,oral infection and so on.Its pathophysiological phase are initiating phase,inflammatory /vascular phase,epithelial phase,ulcer/bacteria phase,recovery phase.Its toxic grading should according to grading standard of World Health Organization（WHO）.

关 键 词：口腔黏膜炎 病理 诊断 

分 类 号：R730.55[医药卫生—肿瘤]