乳腺癌基质金属蛋白酶13蛋白的表达及其与预后的关系  

Expression of MMP-13 in breast cancer and its relationship with prognosis of breast cancer

作　　者：李春耕[1] 李洪涛[2] 

机构地区：[1]河北省唐山市中医院肛肠科,唐山063000 [2]天津医科大学附属肿瘤医院乳腺一科,天津300070

出　　处：《第二军医大学学报》2007年第9期960-963,共4页Academic Journal of Second Military Medical University

基　　金：河北省自然科学基金(052761689).~~

摘　　要：目的:探讨基质金属蛋白酶13(MMP-13)在乳腺癌中的表达情况及其与临床预后的关系。方法:采用组织芯片及免疫组化SP法检测了183例乳腺癌组织中MMP-13的表达水平,分析乳腺癌组织中MMP-13的表达情况与临床病理因素之间的相关性,并结合完整的10年随访资料探讨MMP-13与乳腺癌预后的关系。结果:乳腺癌组织中MMP-13的阳性表达率(54.1%)显著高于良性乳腺疾病(13.3%,P<0.01)。MMP-13的表达与临床TNM分期、淋巴结转移状态、组织学分级密切相关(P<0.01),而与肿瘤大小、年龄、月经状态、病理类型以及雌孕激素受体状态无关。MMP-13高表达组10年生存率低于低表达组(P<0.01)。结论:MMP-13在乳腺癌中表达水平升高,其高表达预示预后不良。Objective： To investigate the expression of MMP-13 in breast cancer tissues and its relationship with clinical prognosis of patients. Methods： Tissue microarray and immunohistochemical SP method were used to detect the expression of MMP-13 in 183 specimens of breast cancer. The association between the expression of MMP-13 and the clinicopathologic parameters of patients was analyzed; the association between MMP 13 and the prognosis of breast cancer was also discussed based on 10 years＇ follow-up data, Results： The positive rate of MMP-13 in the breast cancer tissue （54. 1 %） was significantly higher than that in the benign breast tissues （13.3%, P〈0. 01）. MMP 13 expression was significantly correlated with the clinical TNM stage, histological grade and lymph node metastasis status of the malignancy（P〈0. 01）, but was not correlated with patients＇ age, tumor size, pathological type, period status, and the status of estrogen receptor and progesterone receptors, The 10-year survival rate of patients with over expression of MMP 13 was lower than patients with low MMP 13 expression （P〈0. 01）. Conclusion： MMP 13 expression is upregulated in breast cancer tissues, which is an indicator of poor prognosis of patients.

关 键 词：乳腺肿瘤 基质金属蛋白酶13 组织芯片 诊断 预后 

分 类 号：R737.9[医药卫生—肿瘤]