COX-2在慢性白血病骨髓细胞中的表达及其意义  

Expression of Cyclooxygenase-2 in Bone Marrow Cells of Chronic Leukemia and Its Significance

作　　者：鲍振华[1] 李广伦[1] 于军红[1] 

机构地区：[1]青岛大学医学院附属医院血液科,青岛266003

出　　处：《中国实验血液学杂志》2007年第5期923-926,共4页Journal of Experimental Hematology

摘　　要：本研究探讨慢性白血病患者骨髓细胞COX-2的表达水平及其作用机制和意义。采用Western blot方法检测了67例慢性白血病患者骨髓细胞COX-2及内参照β-actin的表达水平,以14名健康供者骨髓为阴性对照。结果表明:CML-CP组COX-2的阳性表达率为76.32%(29/38),高于对照组,有显著统计学意义(p=0.0000),CLL组COX-2的阳性表达率为75.86%(22/29),高于对照组,有显著统计学意义(p=0.0000)。COX-2在CML-CP组和CLL组的表达水平差别无统计学意义(p>0.05)。COX-2阳性组LDH水平高于COX-2阴性组,差别有统计学意义(p<0.001)。结论:在慢性髓系白血病慢性期和慢性淋巴细胞白血病中均表达COX-2,而且LDH水平也偏高。The study was aimed to investigate the expression of COX-2 in bone marrow cells of chronic leukemia patients and its potential pathogenetic implications. Western blot was applied for detecting COX-2 expression levels in bone marrow cells of 67 chronic leukemia patients and β-actin expression levels. Bone marrow aspirations from 14 healthy donors were used as negative controls. The results showed that the positive rates of COX-2 in chronic-phase group of chronic myeloid leukemia （CML-CP） and in group of chronic lymphocytic leukemia （CLL） were 76.32% （29/38） and 75. 86% （22/29） respectively. Both CML-CP and CLL group showed a higher expression than control group （p = 0.0000, p = 0.0000 respectively）. The expression of LDH in Cox-2 positive group was higher than that in Cox-2 negative group, and the difference between the two groups was statistically significant （p 〈0.001 ）. It is concluded that the expression of COX-2 protein can be detected in bone marrow cells of CML-CP and CLL and the expression level of LDH were higher in cells of CML-CP and CLL. The expression of COX-2 may be correlated with prognosis of CML-CP and CLL.

关 键 词：环加氧酶-2 慢性白血病 骨髓细胞 

分 类 号：R733.72[医药卫生—肿瘤]