ER、PR、PS2在胃癌组织中的表达及临床意义  

THE EXPRESSION OF ER,PR and PS2 IN GASTRIC CARCINOMA AND THEIR CLINICAL SIGNIFICANCE

作　　者：周岩[1] 张成武[2] 窦拉加[2] 

机构地区：[1]青海大学医学院 [2]青海大学附属医院肿瘤外科

出　　处：《青海医学院学报》2007年第3期179-182,共4页Journal of Qinghai Medical College

摘　　要：目的探讨ER、PR及PS2蛋白在胃癌组织中的表达及临床意义。方法用IHC(免疫组化)S-P法检测80例胃癌组织中ER、PR和PS2等3种指标的表达,分析这3种指标表达之间的相关性及与临床病理因素间的关系。结果胃癌组织中ER、PR及PS2阳性表达率分别为38.75%(31/80)、36.25%(29/80)、43.75%(35/80),ER与PR表达强度呈正相关(rs=0.966,P<0.01),而ER、PS2、PR与PS2表达强度呈负相关(rs=-0.357,P<0.01;rs=-0.329,P<0.01);ER、PR和PS2阳性表达在BorrmannⅠ、Ⅱ型与BorrmannⅢ、Ⅳ型之间存在显著性差异;各分组中的ER、PR阳性表达率在分化程度、淋巴结转移数目上存在显著性差异(P<0.05),而各分组中PS2阳性表达率在分化程度、淋巴结转移数目上无显著性差异(P>0.05)。结论ER、PR的表达可能与胃癌发生、生长方式以及淋巴结转移等因素密切相关,PS2的表达可能与胃癌生长方式有关。Objective To explore the expressions of ER, PR and PS2 in gastric carcinoma and their clinical significance. Methods The expressions of ER, PR and PS2 in 80 cases of gastric carcinoma were assayed by Immunohistochemistry（IHC）, analyzing the correlations among them and clinicopathological significance. Results The positive expression rates of ER, PR and PS2 were 38.75% （31/80）, 36.25% （29/80）, 43.75% （35/80） respectively. The expression of ER showed a positive correlation with the expressions of PR（rs = 0. 966,P 〈0.01 ）, while the expressions of ER and PS2, PR and PS2 showed a negative correlation between them （ rs = - 0. 357, P 〈 0.01 ;rs = -0. 329 ,P 〈0.01 ）, The positive expression of ER, PR didnl show significant difference with the neg- ative expression of PS2 . The positive expression of ER, PR and PS2 respectively had the significant difference between Borrmann Ⅰ, Ⅱ and Borrmann Ⅲ, IV. The positive expression of ER , PR had the significant difference in differentiated degree, lymph node shift number （P 〈0.05 ） ,while the positive expression of PS2 was on the contrary （ P 〉 0.05 ）. Conclusion The expressions of ER, PR may closely related with the pathogenisis growth way , and the lymph node shift. While the expressions of PS2 correlated with the growth way in gastric carcinoma.

关 键 词：胃癌 雌激素受体 孕激素受体 PS2蛋白 

分 类 号：R735.2[医药卫生—肿瘤]