葛根素及尼莫地平治疗血管性头痛疗效对比研究  

Comparison study on puerarin and nimodipine in the treatment of patients with vascular headache

作　　者：孙明谨[1] 高才兵[2] 李雪锋[1] 曾玉琴[1] 

机构地区：[1]郧阳医学院附属太和医院内分泌科,湖北省十堰市442000 [2]荆门职业技术学院医学院

出　　处：《实用诊断与治疗杂志》2007年第10期745-747,共3页Journal of Practical Diagnosis and Therapy

摘　　要：目的:观察葛根素及尼莫地平注射液对血管性头痛的治疗效果。方法:将158例血管性头痛患者随机分为两组:葛根素治疗组(A组)78例及尼莫地平治疗组(B组)80例,治疗前后均采用经颅多普勒对血管性头痛患者进行检测分别观察其治疗前后收缩期峰值血流速度、脉动指数的变化,并观察其治疗效果。结果:葛根素及尼莫地平注射液治疗血管性头痛均有显著效果(P<0.05),颅内血管收缩期峰值血流速度及脉动指数有显著恢复(P<0.05)。尼莫地平组对颅内血管峰值血流速度及脉动指数恢复更明显(P<0.05),但两组治疗总有效率无明显差别。结论:葛根素及尼莫地平注射液均能显著改善脑循环和调节血流量,对血管性头痛具有显著疗效。二者短期治疗有效率差别无统计学意义。Objective To study the different effect of puerarin and nimodipine in the treatment of patients with vascular headache. Methods One hundred and fifty-eight patients with vascular headache were randomly divided into group A and B. Seventy-eight patients in group A were given puerarin injection, while the other 80 patients in group B were given nimodipine injection. The therapeutic effects, Vs and PI detected with TCD were compared between two groups. Results The effect in all patients was significantly different （P 〈 0. 05） and the Vs and PI in two groups were recovered significantly （P〈0.05） after treatment. The effect of Vs and PI in group B was more significantly different than in group A （P〈0.05）, but the total effective rate was not significantly different in two groups after treatment （P〉0.05）. Conclusion The curative effect of puerarin and nimodipine is certain in treatment of vascular headache, which can improve hemodynamics. The total effective rate is not significantly different after treatment with puerarin and nimodipine in short time.

关 键 词：血管性头痛 葛根素 尼莫地平 经颅多普勒 

分 类 号：R741[医药卫生—神经病学与精神病学]