泮托拉唑钠工业合成路线评述  

A Review on the Synthesis of Pantoprazole Sodium

作　　者：宋伟国[1] 张福建 徐文方[1] 

机构地区：[1]山东大学药学院,山东济南250012 [2]寿光富康制药有限公司,山东寿光262700

出　　处：《齐鲁药事》2007年第9期555-557,共3页qilu pharmaceutical affairs

摘　　要：泮托拉唑钠是全球第三个上市的H+,K+-ATP酶抑制剂,主用于胃溃疡系统疾病的治疗,近年来,国外对其化学合成研究较多,本文对其中五条具有工业化参考价值的合成路线进行评述。Pantoprazole sodium is the third launched of the H^＋ -K^＋ -ATPase inhibitor in the world, which is mainly used for ulcer disease treatment. In recent years, more and more investigations on the synthesis of pantoprazole sodium has been reported on abroad,among these, Five industrialization synthetic routes are reviewed.

关 键 词：泮托拉唑钠 合成H+^ K^+ -ATP酶抑制剂 

分 类 号：TQ460.31[化学工程—制药化工]