口腔鳞癌中血管细胞黏附分子-1的表达与巨噬细胞浸润的关系  

Correlation between expression of vascular cell adhesion molecule-1 and macrophage infiltration in human oral squamous cell carcinoma

作　　者：孙乐刚[1] 刘玲[2] 宋宇峰[3] 

机构地区：[1]山东滨州医学院附属医院口腔外科,256603 [2]山东滨州医学院附属医院胃镜室,256603 [3]贵阳医学院附属医院口腔外科

出　　处：《实用口腔医学杂志》2007年第5期648-651,共4页Journal of Practical Stomatology

基　　金：贵州省第二批跨世纪人才省政府专项基金(编号:黔科合人专字2000-9813号);贵州省优秀科技教育人才省长专项基金资助(编号:黔科教办[2004]07号)

摘　　要：目的:探讨血管细胞黏附分子-1(vascular cell adhesion molecule-1,VCAM-1)在口腔鳞癌巨噬细胞浸润、聚集中的作用及意义。方法:应用免疫组化二步法检测口腔鳞癌组织中VCAM-1的表达和巨噬细胞的浸润情况,光镜下进行巨噬细胞计数和VCAM-1表达的分级。结果:口腔鳞癌组织中VCAM-1的表达率(64.58%)和巨噬细胞计数(81.04±12.00)显著高于正常口腔黏膜组织(P<0.05);口腔鳞癌组织中VCAM-1的表达与肿瘤的浸润和转移有关(P<0.01),并与肿瘤组织中巨噬细胞浸润有关(P<0.01)。结论:VCAM-1可能对巨噬细胞在口腔鳞癌中的浸润、聚集起调节作用,参与肿瘤的浸润和转移。Objective： To investigate the role of vascular cell adhesion molecule-1 （VCAM-1）on macrophage infiltration and recruitment in oral squamous cell carcinoma（OSCC）. Methods：After detecting the expression of VCAM-1 and macrophage infiltration in OSCC by immunohistochemistry, light microscope was used for counting macrophages. Results ：The expression level of VCAM-1 （64.58%） and macrophage numbers （81.04 ± 12.00 ） was significantly higher in OSCC than those in normal oral mucosa. The expression of VCAM-1 in OSCC was not only related to the tumor infiltration and metastasis in OSCC（ P 〈 0.01 ） , but also related to macrophage infiltration in OSCC（ P 〈 0.01 ）. Conclusion： VCAM-1 may participate in the tumor infiltration and lymphatic metastasis through regulating the macrophage infiltration and recruitment in OSCC.

关 键 词：口腔鳞癌 血管细胞黏附分子-1 巨噬细胞浸润 

分 类 号：R739.8[医药卫生—肿瘤]