大豆磷脂联合维生素E预防大鼠肺出血和水肿的研究  

The study on the prevention of rat pulmonary hemorrhage and edema with bean phospholipid combined vitamin E

作　　者：孙家娥[1] 朱列伟[1] 徐锦[1] 吴静怡[1] 金勤立[1] 

机构地区：[1]上海医科大学儿科医院儿科研究所,200032

出　　处：《上海医学》1997年第4期210-211,共2页Shanghai Medical Journal

摘　　要：本实验应用雄性大鼠静脉注射肾上腺素造成肺出血、水肿（PH、PE）模型，以及应用静脉注射大豆磷脂（PC）联合维生素E（VE）进行预防的研究。结果显示：PC＋VE能降低死亡率，降低血清脂质过氧化物（LPO），支气管肺泡灌洗液（BALL）中蛋白质及磷脂，肺指数；肺组织切片中肺水肿、出血明显改善，其效果优于单独应用PC。The model of male rat pulmonary hemorrhage and edema (PH, PE) was established with intravenous injection of adrenin, and the effects of prevention with beau phospholipid (PC) or PC add vitamin E (PC+VE) on rat PHand PE were studied. Total protiens and total phspholipids in bronchoalvoar lavage liquid were determined from everyrat. Lung index, serum lipid peroxides and lung pathological examination, including electronmicroscopic examination,were observed, too. The results showed that the mortality rate in the group with PC+VE could be decreased apparently, and lung pathological changes as well as, other biochemical changes were restored to normal. The efficiency in thegroup with PC+VE was batter than that in the group with PC alone.

关 键 词：维生素E 大豆磷脂 肺出血 肺水肿 

分 类 号：R563.601[医药卫生—呼吸系统] R541.630.1[医药卫生—内科学]