腹腔镜引导下^(125)I粒子植入治疗复发性妇科恶性肿瘤的临床观察  

Laparoscopic-guided ^(125)I seeds implantation in the treatment of recurrent gynecologic malignancies

作　　者：朱根海[1] 杨舒盈[1] 李诗运[2] 贺国丽[1] 陈春英[1] 王雁[1] 

机构地区：[1]海南省人民医院妇科,海南海口570311 [2]海南省人民医院核医学科,海南海口570311

出　　处：《中华肿瘤防治杂志》2007年第21期1656-1657,1670,共3页Chinese Journal of Cancer Prevention and Treatment

基　　金：海南省自然科学基金(80458)

摘　　要：目的:探讨腹腔镜下手术切除及125I粒子植入治疗复发妇科恶性肿瘤的可行性及价值。方法:5例复发妇科恶性肿瘤患者在腹腔镜下切除复发癌灶并于切除病灶周边植入125I粒子。结果:随访5～11个月,4例患者血CA125恢复正常,检查肿瘤消失,并且未出现新的病灶;1例患者血CA125异常,原切除及植入粒子的部位肿块消失,其他部位出现新的复发灶。未见急性或严重的并发症,所有患者均有一过性CA125升高、肿块切除部位及粒子植入部位隐痛及短期会阴部水肿。结论:腹腔镜下手术切除及125I粒子植入是治疗复发妇科恶性肿瘤可行和有效的方法,但结论尚有待长期随访。OBJECTIVE： To investigate the feasibility and value of laparoscopic resection and ^125I seeds implantation for recurrent gynecologic malignancies. METHODS： Laparoscopic surgery and ^125I seeds implantation at the tumor bed of tumor removal were used in five patients. RESULTS： The procedure was safely a cbieved in all five patients,and four patients were alive with normal CA125 and without tumor after 5-11 months of follow-up. In one patient, new multiple recurrences appeared out of the site of original excision and implantation. No acute complication from the procedure or serious complication was noted. All patients experienced temporary CA125 elevation, slight pain at the implant site, and temporary vulvar dropsy. CONCLUSIONS： Laparoscopic resection and 1251 seeds implantation seem to be feasible and effective methods for recurrent gynecologic malignancies. However, long term follow-up is needed.

关 键 词：生殖器肿瘤 女(雌)性/外科学 腹腔镜检查 碘放射性同位素 

分 类 号：R737.3[医药卫生—肿瘤]