肝硬化患者医院感染调查研究  

Investigation on nosocomial infection in patients with liver cirrhosis

作　　者：梁波[1] 

机构地区：[1]广西医科大学第七附属医院,广西梧州543001

出　　处：《中国感染控制杂志》2007年第5期323-325,共3页Chinese Journal of Infection Control

摘　　要：目的对肝硬化患者医院感染的发生情况进行调查研究,以制定预防对策。方法对某院1999年1月—2006年10月住院的肝硬化患者临床资料进行回顾性分析。结果483例肝硬化患者发生医院感染143例,181例次,医院感染率为29.61%,例次感染率为37.47%。医院感染率比较:肝功能Child-Pugh分级B级、C级者较A级者高,血清蛋白值及白细胞计数低者较其正常者高,有并发症者较无并发症者高,住院时间≥2周者较<2周者高(均P<0.01)。肝硬化合并医院感染者病死率为18.88%(27/143),显著高于未发生医院感染的肝硬化患者病死率6.18%(P<0.01)。结论肝硬化患者医院感染率较高,发生医院感染者预后较差;其医院感染发生与肝功能情况、血清蛋白值、白细胞计数、并发症及住院时间有关,应针对上述因素采取积极有效的措施降低肝硬化患者的医院感染率。Objective To investigate the occurrence of nosocomial infection （NI） in patients with liver cirrhosis, so as to make preventive measures. Methods Clinical data of liver cirrhosis patients hospitalized in a hospital from January 1999 to October 2006 were analysed retrospectively. Results Among four hundred and eighty- three liver cirrhosis patients, 143 developed 181 cases NI, NI rate was 29. 61%, case infection rate was 37. 47%. NI rates were higher in patients with liver function Child - Puge grade B and C than those with grade A, NI rates were also higher in patients with low serum protein value, lower white blood cell count as well as more complications, and patients whose hospitalization time ≥2 weeks had higher NI infection rates than patients whose hospitalization time were 〈2 weeks （both P〈0. 01）. The mortality rate in liver cirrhosis patients with NI was 18. 88% （27/143）, which was obviously higher than that （6. 18%） of patients without NI（P〈0. 01）. Conclusion Liver cirrhosis patients have higher NI rates, and the prognosis is bad, the occurrence of NI is related to the liver function, serum protein value, white blood cell count, the occurrence of complication and duration of hospitalization, effective measures should be taken to reduce NI rate in patients with liver cirrhosis.

关 键 词：肝硬化 医院感染 危险因素 

分 类 号：R575.2[医药卫生—消化系统]