轻中度子宫内膜异位症相关不孕的研究进展  

Research on minimal to mild endometriosis associated infertility

作　　者：陈希婧[1] 黄荷凤[1] 

机构地区：[1]浙江大学医学院附属妇产科医院,浙江杭州310006

出　　处：《浙江大学学报（医学版）》2007年第5期515-520,共6页Journal of Zhejiang University(Medical Sciences)

基　　金：国家973项目(编号:2006CB944006)

摘　　要：子宫内膜异位症是妇科常见病,不孕是其主要临床表现之一。盆腔解剖结构异常被认为是重度内异不孕的主要原因,但轻中度内异患者并不存在明显盆腔结构异常,其不孕原因一直是国内外学者关注的热点。目前认为,轻中度内异患者不孕与盆腔微环境改变密切相关,而且有多种细胞因子和蛋白参与,干扰正常妊娠需经历的排卵、配子运输、受精、胚胎运送、胚胎着床等一系列过程,其中任一环节受阻都可能导致妊娠失败。Endometriosis is a common disease of reproductive age women and infertility is one of its clinical manifestations. Infertility of patients with severe endometriosis may be attributed to the anatomy alteration of pelvis. However, the infertility of patients with minimal to mild endometriosis whose pelvic anatomy remains intact is still hard to explain. It is considered that the infertility of patients with ninimal to mild endometriosis is associated with the alteration of the pelvic microenvironment. Several kinds of cytokines and proteins are involved in this process. They may disturb steps necessary to achieve successful pregnancy, such as ovulation, gamete transport, fertilization,embryo transport and implantation. Any disturbance to one of the steps mentioned above may lead to pregnant loss.

关 键 词：子宫内膜异位症/并发症 不育 女(雌)性/病因学 胚胎和胎儿发育 精子能动性 排卵 胚胎植入 

分 类 号：R711.71[医药卫生—妇产科学]