多西紫杉醇联合5-氟尿嘧啶、亚叶酸钙及草酸铂治疗胃癌肝转移的临床观察  

Clinical Observation of Taxotere in Combination with 5-Fluorouracil,Leucovorin and Oxaliplatin for Hepatic Metastasis of Gastric Cancer

作　　者：刘琳 郭珺 陈阵 王哲海 

机构地区：[1]山东肿瘤医院内三科,济南250117

出　　处：《肿瘤防治研究》2007年第9期708-710,共3页Cancer Research on Prevention and Treatment

摘　　要：目的观察多西紫杉醇联合5-氟尿嘧啶、亚叶酸钙及草酸铂治疗胃癌肝转移的疗效及毒副反应。方法多西紫杉醇50mg/m2,d1,草酸铂100mg/m2,d1,5-Fu750mg/(m2.d)持续静脉滴注48h,d1～2,CF200mg,d1～3,每2周重复。完成3周期后评价疗效。结果全组24例患者,治疗后CR2例,PR12例,RR(CR+PR)为58.3%。中位生存时间(MST)11.2个月,中位疾病进展时间(TTP)6.6个月。主要不良反应为骨髓抑制、神经毒性、粘膜炎等。结论多西紫杉醇联合5-氟尿嘧啶、亚叶酸钙及草酸铂治疗胃癌肝转移有效率较高,可提高患者的生存质量,毒副作用能耐受。Objective To evaluate the effects and adverse reactions of taxotere in Combination with 5-Fluorouracil,Leucovorin and Oxaliplatin regimen for patients with a hepatic metastasis of Gastric Cancer. Methods Taxotere 50mg/ m^2 iv d1, continuous, 5-FU 750 mg/（m^2.d） continuous infusion 48 h d1-2 , CF 200 mg iv d1-3, Oxaliplatin 100 mg/m^2 d1, repeated every 2 weeks. Tumor assessment was done after 3 cycles. Results Among 24 patients, 2 patients reached complete response （CR）, 12 partial responses （PR）. The overall response rate （CR ＋ PR） was 58. 3%. Median survival time was 11.2 months. The median time to progression of all patients was 6. 6 months. The major adverse effect was myelosuppression, mild neurosensory toxicity, and membranitis. Conclusion Taxotere in Combination with 5-Fluorouracil,Leucovorin and Oxaliplatin shows good efficacy in treatment hepatic metastasis of Gastric Cancer. The quality of life can be improved and the toxicity is tolerable.

关 键 词：多西紫杉醇 5-氟尿嘧啶 草酸铂 胃肿瘤 肝转移 

分 类 号：R735.2[医药卫生—肿瘤] R730.53[医药卫生—临床医学]