全肝介入化疗加立体定向放疗治疗中晚期原发性肝癌效果分析  

Effect analysis of entire liver intervention chemotherapy and directional radiotherapy in the treatment of advanced primary liver cancer

作　　者：白光平[1] 时启良[2] 杨洲[1] 

机构地区：[1]阜阳市人民医院放疗科,安徽阜阳236000 [2]阜阳市人民医院放射科,安徽阜阳236000

出　　处：《中华肿瘤防治杂志》2007年第22期1736-1737,共2页Chinese Journal of Cancer Prevention and Treatment

摘　　要：为探讨介入化疗加立体定向放射治疗对中晚期原发性肝癌的临床疗效,对32例患者行全肝化疗后,行立体定向放射治疗,对于病灶集中者设一个适形野,80%等剂量线包绕;对于多个病灶而病灶相距较远者行X刀旋转照射,80%等剂量线包绕。中心最大剂量(3～4)Gy/次,隔日治疗1次,共10～12次。治疗期间使用保肝药物和疏肝理气中药。经以上治疗后患者CR6例(18.8%),PR24例(75.0%),(SD+PD)4例(6.2%)。初步研究结果提示,全肝介入化疗加局部立体定向放疗是治疗中晚期肝癌的有效方法,疏肝理气中药和保肝药物的应用可保护肝脏功能和降低放射线对肝脏的损害。The objective of this study was to discuss the clinical effect of intervention chemotherapy and the three-dimensional direction detection radiotherapy in the treatment of liver malignant tumor. After 32 patients were treated with entire liver chemotherapy and three-dimensional direction detection radiotherapy, a suitable shape was built regarding sickness stove centralized being folded by 80% isodose curve. X knife was executed with circumrotating illumination to the stove regarding many sickness stove being distanced comparatively the far execution. 80 % isodose curve. The largest dose was （3-4） Gy/hypo in the Center. Treatment was performed every other day, for altogether 10-12 times. During the treatment period the Chinese traditional medicine was administered for protection of the liver. After the treatment, CR was 18.8%（6 cases）, PR 75.0%（24 cases）, and （SD＋PD） 6.2%（4 cases）. In conclusion, the entire liver interrention chemotherapy and three-dimensional directional radiotherapy is effective in the treatment of advanced liver cancer, and at the same time, Chinese traditional medicine can protect the liver and reduce the liver harmfulness from the radiotherapy.

关 键 词：肝肿瘤/药物疗法 肝肿瘤/放射疗法 立体定位技术 

分 类 号：R735.7[医药卫生—肿瘤]