鼻咽癌颈淋巴结转移的生物学基础研究  

Biological research on nasopharyngeal carcinoma lymphatic metastasis

作　　者：易炜[1] 夏云飞[1] 

机构地区：[1]中山大学附属肿瘤防治中心放疗科,广东广州510060

出　　处：《中华肿瘤防治杂志》2007年第22期1744-1746,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：鼻咽癌是一种亲淋巴系统转移的恶性肿瘤,颈部淋巴结转移率可高达78.9%,并与预后密切相关,故研究鼻咽癌颈淋巴结转移的生物学机制具有重要的临床意义。目前已进行的研究发现鼻咽癌的颈淋巴结转移与细胞黏附机制、基质金属蛋白酶、肿瘤血管生成、肿瘤细胞基因改变及EB病毒编码膜潜伏蛋白等几方面因素有密切关系,但其确切机制仍未阐明。探究鼻咽癌颈部淋巴结转移的生物学机制可以为临床工作治疗淋巴结转移提供理论指导,从而为进一步提高鼻咽癌的疗效作出贡献。Nasopharyngeal carcinoma is a kind of malignant carcinoma which trends to lymphatic metastasis, and the cervical lymphatic metastasis rate can be as high as 78. 9%o. It has great value to research the mechanism of cervical lymphatic metastasis of NPC. The researchers have found that the cervical lymphatic metastasis of NPC is associated with cell adhesion, matrix metalloproteinase, tumor angiogenesis, gene alteration of tumor cell, EB virus latent membrane protein, etc. However, the precise mechanism is far away from elucidation. The research on the mechanism of lymphatic metastasis of NPC can guide the therapy of lymphatic metastasis and improve the NPC prognosis.

关 键 词：鼻咽肿瘤/病理学 淋巴转移 综述文献 

分 类 号：R739.63[医药卫生—肿瘤]