胃癌患者预后及病理因素与Bmi-1表达的相关性研究  

Expression and clinical significance of Bmi-1 in gastric carcinoma

作　　者：刘建化[1] 黄开红[1] 李学先[1] 宋立兵[2] 郭宝红[2] 冯艳[2] 曾木圣[2] 

机构地区：[1]中山大学附属第二医院消化内科,广东广州510120 [2]中山大学肿瘤防治中心实验研究部,广东广州510060

出　　处：《中国病理生理杂志》2007年第10期2018-2022,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.30670951);广东省自然科学基金资助项目(No.5001749No.06021322);广州市科技攻关资助项目(No.2003Z3-E0351);广东省科技攻关项目(No.2005B31211002)

摘　　要：目的:探讨胃癌组织中Bmi-1蛋白的表达与胃癌患者病理因素及预后的相关性。方法:收集我院2002-2004年146例有3年以上完整随访资料的胃癌术后患者,采用免疫组织化学法对手术标本石蜡切片进行染色,检测Bmi-1蛋白的表达情况,并分析该蛋白表达对胃癌患者临床病理因素及预后的影响。结果:Bmi-1蛋白在本组胃癌中阳性表达率为67.8%(99/146)。Bmi-1的表达与胃癌大小、临床分期、淋巴结转移和侵润深度密切相关(P<0.05),而与患者的性别、年龄、肿瘤分化程度等无关(P>0.05)。Bmi-1阳性表达者生存率明显低于阴性者(P<0.01)。多因素分析显示,Bmi-1表达、癌侵润深度、淋巴结转移、远处转移、肿瘤大小、术后化疗均为具有显著统计学意义的影响预后的因素。结论:Bmi-1在胃癌组织表达状态与胃癌的生长和侵润转移关系密切,可以作为反映胃癌生物学行为和判断预后的有效指标。AIM： To investigate the relationship between expression of Bmi - 1 （ B cell - specific MLV integration site - 1 ） in gastric cancer and its clinicopathologic significance. METHODS： 146 surgical patients with gastric carcinoma were followed up at least 2 years. Expression of Bmi - 1 protein was examined by immunohistochemistry in their archival paraffin embedded tissue specimens. RESULTS： The intensive positive rate of Bmi - 1 expression in gastric cancer was 67.8% （99/146）. Expression of Bmi - 1 was highly correlated with tumor size, clinical stage, lymph node metastasis and T classification （P 〈0.05）, but not with sex, age, tumor differentiation, etc. （P 〉0. 05）. The survival rate in the patients with Bmi- 1 expression was much lower than that in those patients without Bmi- 1 expression （P 〈0. 01 ）. Multivariate analysis indicated that Bmi - 1 expression, T classification, lymph node metastasis, distant metastasis, tumor size and postoperative chemotherapy were all significantly prognostic factors of gastric carcinoma. CONCLUSION： Overexpression of Bmi - 1 in patients with gastric carcinoma enhances the possibility of invasion and metastasis, implying a poor prognosis. Bmi - 1 may serve as fairly a good prognostic factor to indicate biologic behavior and prognosis in gastric carcinoma.

关 键 词：胃肿瘤 BMI-1 肿瘤侵润 预后 

分 类 号：R363[医药卫生—病理学]