亚硝酸钠对饲克山病病区粮大鼠花生四烯酸代谢影响  

Effects of NaNO 2 on arachidonic acid metabolism of Wistar rats fed with grain from Keshan disease area

作　　者：刘为民 张秀云 李广生 岳丽杰 孙波 邹雅斌 王凡 马力 肖淑芬 

机构地区：[1]应用基础医学研究所 [2]第一临床学院核医学科

出　　处：《白求恩医科大学学报》1997年第3期225-227,共3页Journal of Norman Bethune University of Medical Science

基　　金：国家"八五"攻关项目

摘　　要：以低硒（Ｓｅ）低维生素Ｅ（ＶＥ）的克山病病区粮饲养大鼠１０周，用腹腔注射亚硝酸盐引起急性缺氧的方法，观察花生四烯酸代谢及其主要产物水平的变化。结果表明，病区粮组大鼠磷脂酶Ａ２活力、花生四烯酸含量、血栓素水平、血栓素／前列环素比值增高；前列环素水平、抗氧化酶活力降低；补Ｓｅ和ＶＥ可使上述变化逆转。结果提示，花生四烯酸代谢紊乱、抗氧化能力降低，是亚硝酸钠与Ｓｅ和ＶＥ缺乏协同引起心肌损害的作用环节。The inceases in the phospholipase A 2 activity,arachidonic acid content,thromboxane A(TXA 2)level and TXA 2 /prostacylin(PGI 2)accompanied with decrease of PGI 2 and antioxidases activities were observed in Wiustar rats which were maintained on low selenium(Se) and vitamin E (VE)diets from Keshan disease endemic area for 10 weeks and which were injected NaNO 2 for days.The results suggest that metabolic disorder of arachidonic acid may take part in the mechanism of myocardial lesion caused by injecting NaNo 2 and deficiency of Se and VE.

关 键 词：花生四烯酸 亚硝酸钠 克山病 

分 类 号：R542.302[医药卫生—心血管疾病]