黄花石蒜对老年痴呆小鼠的药效学研究  

The Therapy Effect of Lycoris Aurea on the AD Model Mice

作　　者：皮慧芳[1] 阮汉利[1] 张鹏[1] 朱田[1] 张勇慧[1] 吴继洲[1] 

机构地区：[1]华中科技大学同济医学院药学院,湖北武汉430030

出　　处：《中华中医药学刊》2007年第10期2049-2050,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(30572312)

摘　　要：目的:研究黄花石蒜对老年痴呆(AD)模型小鼠学习记忆能力的影响。方法:选用昆明种小鼠,皮下注射东莨菪碱(2mg.kg-1)制备老年痴呆小鼠模型,通过Y型水迷宫实验来观察黄花石蒜对AD模型小鼠学习记忆的影响。结果:与模型组比较,黄花石蒜醇提物高剂量组(40.2g生药.kg-1)和低剂量组(20.1g生药.kg-1)均能明显缩短AD模型小鼠Y型水迷宫测试的潜伏期(P<0.05),减少其上岸错误次数(P<0.05),明显改善小鼠学习记忆。结论:黄花石蒜醇提物能改善AD小鼠的学习记忆能力。Objective： To study the therapy effect of Lycoris aurea on the AD model mice. Methods： KM mice were trained by Y - maze and their learning - memory abilities were detected before injection of scopolamine. Then the mice were divided into four groups on the basis of conditions, of which the same level of learning - memory abilities each group. The mice were orally administrated with different doses of Lycoris aurea for 50d. The learning - memory abilities were detected on 24 d, 50 d by Y - maze swimming testing. Results ： Compared with model group, the learning - memory abilities of the mice orally administrated with Lycoris aurea（40.2g crude drug ·kg^-1 , 20. lg crude drug·kg^-1 ） was better, the delitescence to reach destination was obviously shorter （ P 〈 0. 05）, error times of getting ashore were remark- ably decreased （ P 〈0.05）. Conclusion： Lycoris aurea can improve the learning- memory abilities of scopolamine -induced mice to show the activity, which provided evidence for separating simple activity substances.

关 键 词：黄花石蒜 老年痴呆 东莨菪碱 

分 类 号：R-33[医药卫生] R285.5