针刺对实验性缓慢性心律失常大鼠延髓G_i mRNA表达的影响  

Study on Acupuncture Experiment Effect on Bradyarrhythmia Rat G_imRNA Expression in Bulbus Medullae

作　　者：阎醒予[1] 曹震[1] 陈颖 郑利岩[1] 张小卿[1] 岳志军[3] 

机构地区：[1]辽宁中医药大学 [2]解放军93303部队卫生队 [3]辽宁中医药大学附属医院

出　　处：《中华中医药学刊》2007年第10期2097-2099,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：辽宁省教育厅高等学校科学研究项目(05L252)

摘　　要：目的:探讨针刺内关穴调节缓慢性心律失常的效应机理。方法:电针异搏定所致的缓慢性心律失常模型大鼠双侧"内关"穴,观察针刺前后心律(率)变化;用半定量逆转录聚合酶链反应(RT-PCR)方法测定延髓中抑制性G蛋白(Gi)mRNA的相对含量。结果:针刺治疗组与模型组相比有显著变化(P<0.05)。结论:缓慢性心律失常可能和延髓中G蛋白基因表达障碍有关;G蛋白在针刺内关穴对心律失常的调节中有重要作用。Objective ：To explore mechanism of acupuncture Neiguan point to bradycardia regulation. Methods ：Arrhythmia was induced with cordilox, and acupuncture two - side ＂Neiguan＂ by electro - acupuncture later. Observe the change cardiac rhythm and rate;The expression of G1mRNA in bulbus medullae was detected by using reverse transcription polymerase chain reaction（RT-PCR）. Results ： Acupuncture treatment group has signifcent change compared with model group （ P 〈 0. 05 ）. Conclusion ：Arrhythmia probably related with G protein genetic in bulbus medullae expression disordering,which was very important to regulate arrhythmia by acupuncture Neiguan point.

关 键 词：针刺 内关 心律失常 延髓 抑制性G蛋白 RT-PCR 

分 类 号：R-33[医药卫生]