外周原始神经外胚层肿瘤15例临床病理分析  

PATHOLOGICAL ANALYSES OF 15 CASES OF PRIMITIVE NEUROECTODERMAL TUMOR

作　　者：王世峰[1] 王琪[2] 马利明 

机构地区：[1]临沂市人民医院,山东临沂276000 [2]临沂市中医医院 [3]临沂市兰山区第一人民医院

出　　处：《山东医学高等专科学校学报》2007年第5期343-345,共3页Journal of Shandong Medical College

摘　　要：目的探讨外周原始神经外胚层肿瘤（PNET）的临床表现、病理、免疫组织化学特点及预后。方法对15例外周原始神经外胚层肿瘤进行病理组织形态学免疫组化表型及预后研究。结果患者以男性为主，男女之比为6．5：1，年龄6～35岁，中位数为16岁。发生部位：多为直肠、腹膜后、腹股沟、淋巴结、胸壁、鼻腔及骨组织等；免疫组化：肿瘤均弥漫表达CD99，并不同程度地表达NSE、SYN、CgA等，但对CK、Desmin、LCA等不表达。随访时间为3～24个月。结论PNET是一种多发生在年轻男性、进展迅速、预后非常差的恶性小圆细胞肿瘤，认识其临床病理特点及免疫组化表型对于该恶性肿瘤的诊断及临床治疗意义重大。Objective To explore the clinical manifestations and pothological, immunohistochemical and prognositic features of primitive neuroectodermal tumor（PNET）. Methods 15 cases of PNET were studied in terms of histopathological, immunohistochemical and prognostic features. Results The ratio of male and female patients was 6.5：1, Their ages range from 6 to 35, with the median age being 16. The attacks were located in rectum, retroperitoneum, inguina, lymph node, chest wall, testis, nail cavity and bone tissues. All tumors showed diffuse expression of CD99 and different degrees of NSE, SYN and CgA expressions. No CK, surveys lasted 24 months, Conclusion PNET mainly attacks young males and has poor prognosis. The clinical pathological features and immuno histochemical expressions can help to diagnose the disease.

关 键 词：原始神经外胚层肿瘤 免疫组化 组织形态学 临床特点 预后因素 

分 类 号：R730.264[医药卫生—肿瘤]