食管癌三维适形放疗联合多西它塞同期化疗的临床研究  

Three dimensional conformal radiotherapy combined with taxotere for patients with esophageal carcinoma

作　　者：毕益明[1] 付艳[1] 刘百百[1] 陈兴秀[1] 陈秀芳[1] 李全奎[1] 杨金山[1] 王淑燕[1] 

机构地区：[1]山东省滨州市人民医院,山东滨州256610

出　　处：《现代肿瘤医学》2007年第11期1607-1608,共2页Journal of Modern Oncology

摘　　要：目的:探讨三维适形放疗(3D-CRT)联合多西它塞同步化疗在食管癌治疗中的近期有效率、毒性反应及生存期。方法:48例病人根据入选标准进入研究。化疗为多西它塞25mg/m2,每周1次。放疗第1天开始应用,采用三维适形放疗,95%PTV59.4Gy/33次/6.5周。结果:完全缓解率为72.92%;近期总有效率(CR+PR)为91.67%。1年及3年局部控制率分别为89%、65%,1年及3年生存率分别为85.3%、60.7%。放化组毒性反应主要是放射性食管炎,其次是血液学毒性,患者均能耐受。结论:三维适形放疗联合多西它塞化疗对食管癌近期疗效较好,虽毒性反应增加但病人可以耐受。To evaluate the effect and toxicity of three dimensional conformal radiotherapy（3D - CRT） concurrent taxotere for patients with esophageal carcinoma. Methods： Forty - eight patients with esophageal carcinoma were received 3D - CRT concurrent taxotere, the radiotherapy was carried out by 3D - CRT , to a total dose 95% PIN 59.4Gy/33Fr/6.5W. Results ： Complete response rate（CR） was 72.92%. Overall response rate （ CR ＋ PR） was 91. 67%. The local control rates of 1 year and 3year were 89% and 65% , respectively. The survival rates of 1 year and 3 year were 85.3% and 60.7%, respectively. The main acute toxic effect was radioactive esophagitis . Conclusion： Three dimension conformal radiotherapy（3D-CRT） concurrent taxotere, could improve the overall resoonse rate and survival rate of esoohageal carcinoma, but it increase the acute toxic effct.

关 键 词：三维适形放疗 食管癌 化疗 

分 类 号：R735.1[医药卫生—肿瘤]