青年胃癌发病与病理特点分析  

Incidence and pathological characters of young patients with gastric carcinoma

作　　者：李晓军[1] 王岭[1] 易军[1] 允军[1] 王辉[1] 

机构地区：[1]第四军医大学西京医院血管内分泌外科,陕西西安710032

出　　处：《现代肿瘤医学》2007年第11期1626-1628,共3页Journal of Modern Oncology

摘　　要：目的:分析青年胃癌的发病特点和病理特征,为青年胃癌的预防和治疗提供理论依据。方法:对我院1983年～2005年收治的1839例患者资料进行筛选和研究,并对青年胃癌的性别、发病年龄和不同病理学类型进行分析,评价遗传因素在胃癌发病中的作用。结果:青年胃癌以弥漫型多见(40.49%),病理分型多为低分化腺癌、黏液细胞癌和印戒细胞癌,恶性程度高,女性发病年龄更低,男女性比例接近。具有家族遗传背景或遗传性胃癌患者中青年发病者多于中老年(39/189vs69/1454,P<0.001;16/189vs21/1454,P<0.001),男性更易受遗传因素影响。结论:青年胃癌以高度恶性弥漫型为主,发病呈上升趋势,且与遗传背景具有一定的相关性,临床上应提高警惕,特别是对于具有遗传背景的高危人群。To analyze the incidence characters of gastric cancer on the young patients, and to explore possibility to the screen and prevent hereditary gastric carcinoma. Methods： All 1839 gastric cancer inpatients＇data during 1983 ～ 2003 in 1 Affiliated Hospitals of the Fourth Military Medical University were collected. The characters of incidence included sex, age, pathological type and hereditary effect were analyzed. Results： The youth with the hereditary background or in hereditary gastric cancer （HGC） kindred had a high possibility to develop the disease （ 39/189 vs. 69/1454, P 〈 0.001 ; 16/189 vs. 21/1454, P 〈 0.001 ）, and the male had a higher probability . Diffused gastric cancer was popular in the young patients （40.49%）. The lists of pathological type were poorly differentiated adenocarcinoma, Krukenberg tumor, and signet-ring cell carcinoma, all had a bad prognosis. Conclusion： The gastric cancer in young presents an increase tendency and most of them are poorly differentiated. The incidence of young gastric cancer patients show a correlation to the hereditary factor, which suggests more attention should be oaid to the youth exoosed in the high gastric cancer HGC background.

关 键 词：胃癌 青年 病理 遗传 

分 类 号：R735.2[医药卫生—肿瘤]