视网膜母细胞瘤组织发生的探讨  

Evaluation of Histogenesis of Retinoblastoma

作　　者：贾平凡[1] 王新允[2] 郑海燕[2] 

机构地区：[1]天津市第一中心医院,300192 [2]天津医科大学病理教研室

出　　处：《天津医药》1997年第5期285-287,共3页Tianjin Medical Journal

摘　　要：应用免疫组织化学方法探讨视网膜母细胞瘤的组织来源。结果显示;神经胶质细胞标记物GFAP(12/25)、神经元标记物NSE(18/25)、S-100蛋白(10/25)瘤细胞呈不同程度的阳性反应。Vimentin瘤细胞全部呈阴性反应。结果提示:视网膜母细胞瘤来源于神经外胚层上皮,向神经元和光感受器方向分化。神经胶质细胞可能是反应性增生,但也不排除向神经胶质细胞方向分化的可能性。The results of immunohistochemical study and the histogenesis of retinoblastoma were discussed. Immunohistochemical studies revealed that 12/25 cases were positive for GFAP, 18/25 cases were positive for NSE, 10/25 cases were positive for protein S-100,and all cases were negative for vimentin. The results suggested that retinoblastoma originated from the retinoblast with potential of differentiation into photoreceptors and neurons. The glial components pertained to reactive gliosis, however, the rare possibility of differentiation into glial cell could not be ruled out.

关 键 词：视网膜母细胞瘤 免疫组化 组织发生 视网膜肿瘤 

分 类 号：R739.720.2[医药卫生—肿瘤]