中药淫羊藿联合有氧运动对大鼠骨髓组织FN表达的影响  

Effects of the Combination of Traditional Chinese Medicine and Aerobic Exercise on Expression of FN in Myeloid Tissue of Rats

作　　者：王松[1] 沈霖[1] 杨月琴[2] 金丽[2] 高凤[2] 

机构地区：[1]华中科技大学同济医学院附属协和医院中西医结合骨科,武汉430022 [2]武汉体育学院运动人体科学系

出　　处：《中国中医骨伤科杂志》2007年第10期11-13,共3页Chinese Journal of Traditional Medical Traumatology & Orthopedics

基　　金：湖北省自然科学基金(2004ABA208).

摘　　要：目的:探讨淫羊藿及有氧运动对去势Wister大鼠骨髓组织的FN表达的影响。方法:应用SABC免疫组织化学方法,分析比较去势Wister大鼠经中药(淫羊藿)、有氧运动(游泳)以及两者联合作用后FN在腰椎骨髓组织中的表达情况。结果:(1)运动+灌药组(SM组)的腰椎骨髓组织细胞的FN表达呈阳性表达,但少见破骨样细胞呈阳性表达;(2)运动组(S组)及灌药组(M组)的腰椎骨髓组织中破骨样细胞的FN表达呈阳性;(3)病理组(OVX组)腰椎骨髓组织中破骨样细胞的FN表达呈强阳性。结论:FN主要分布于腰椎骨髓组织的细胞间质及破骨细胞样细胞的胞浆和胞膜上;淫羊藿及有氧运动使FN在去势Wister大鼠骨髓组织中的破骨样细胞中表达减弱。To observe the influence of Traditional Chinese Medicine（TCM）and/or aerobic exercise on FN in lum bar myeloid tissue of ovariectomized Wister rats. Methods： Immunohistochemical ABC methods was used to determine FN in lumbar myeloid tissue of ovariectomized Wister rats that were treated by various methods. The treatment methods were： TCM,exercise,a combination of TCM and exercise and a control group. Results： （1）Expression of FN was the highest in lumbar myeloid tissue and was the least in osteoclast like cells in the group which was treated by TCM combined with exer cise. （2）Expression of FN was higher in osteoclast like cells in both the TCM group and the exercise group. （3）Expression of FN was the highest in osteoclast like cells in the control group. Conclusion： FN was located in the intercellular substance and in the endochylema and the membrane of the osteoclast-like cells; The account of FN in osteoclast like cells of ovariectomized Wister rats is reduced by TCM and/or aerobic exercise.

关 键 词：中药 淫羊藿 有氧运动 纤连蛋白(FN) 

分 类 号：R-33[医药卫生] R681