Caspase-7、Caspase-3、Survivin与乳腺癌新辅助化疗的关系  

Correlation between expression of Caspase-7,Caspase-3,Survivin and neoadjuvant chemotherapy in breast neoplasm

作　　者：周士福[1] 胡会华[1] 李青国[1] 

机构地区：[1]苏州大学附属无锡第四医院,江苏无锡214062

出　　处：《山东医药》2007年第27期12-13,共2页Shandong Medical Journal

摘　　要：目的探讨新辅助化疗疗效与Caspase-7、Caspase-3、Survivin的关系。方法用免疫组织化学法检测46例乳腺癌新辅助化疗前后石蜡包埋福尔马林固定标本Caspase-7、Caspase-3、Survivin的表达变化。结果新辅助化疗有效率为80.43%。Caspase-7新辅助化疗前后阳性率分别为67.39%、86.96%,P<0.05;Caspase-3分别为63.04%、84.78%,P<0.05;Survivin分别为71.74%、47.83%,P<0.05。化疗前Caspase-7与Caspase-3阳性者化疗疗效好于阴性者(P均<0.05)。结论Caspase-7、Caspase-3、Survivin的表达变化与新辅助化疗疗效密切相关。[ Objective ] To study the relationship between neoadjuvant chemotherapy and Caspase-7, Caspase-3, Survivin gene. [ Methods ] Expression of Caspase-7, Caspase-3 and Survivin were examined by immunohistoehemistry in 46 breast neoplasm patients treated with neoadjuvant chemotherapy. [ Results] The overall response rate of neoadjuvant chemotherapy was 80.43%. The expression of Caspase-3 and Caspase-7 were significantly increased after chemotherapy （P 〈 0.05 ） , while that of survivin was decreased （P 〈 0.05 ）. Compared with Caspase-7 or Caspase-3 negative cases, positive cases were sensitive to chemotherapy （ P 〈 0.05 ）. [ Conclusions] Up-regnlatod Caspase-3, Caspase-7 and down-regnlatod Survivin correlate with the response rate of neoadjuvant chemotherapy.

关 键 词：乳腺肿瘤 新辅助化疗 CASPASE-7 CASPASE-3 SURVIVIN 

分 类 号：R737.9[医药卫生—肿瘤]