立体定向适形放疗肝转移瘤临床疗效多因素分析  

Analysis of prognostic factors for patients with liver metastasis treated by three-dimensional conformal radiotherapy

作　　者：闫丽[1] 梁军[2] 

机构地区：[1]临沂市人民医院 [2]青岛大学医学院附属医院

出　　处：《山东医药》2007年第27期22-23,共2页Shandong Medical Journal

摘　　要：目的探讨立体定向适形放疗治疗肝转移瘤的预后因素。方法39例肝转移瘤患者接受立体定向适形放疗，共3—6周，肝转移瘤放疗剂量52—68Gy，平均58．8Gy，25例放疗前曾接受化疗。用Log—rank法比较各组患者的中位生存期，用单因素分析和COX回归模型多因素分析。结果39例中位生存期为14个月。单因素分析结果显示，患者的预后与肝转移瘤体积大小、数目、位置、放疗剂量、治疗时间、化疗、KPS评分有关。多因素分析显示放疗剂量、化疗是影响预后的重要因素。结论立体定向适形放疗是治疗肝转移瘤的有效方法，放疗剂量和化疗是重要的独立的预后因素。[ Objective] To explore the prognostic factors affecting the survival of patients with liver metastasis treated by three-dimensional conformal radiotherapy. [ Methods] 39 patients with liver metastasis treated by three-dimensional conformal radiotherapy were studied retrospectively. 25 patients received chemotherapy before radiotherapy. A dose of 52-68 Gy/3-5 weeks was used, the median survival time was compared by Log-rank test. The possible prognostic factors were analyzed by univariate analysis and muhi-variate analysis with COX proportional hazard model. [ Results ] Overall patients, median survival time was 14 months. The significant prognostic factor demonstrated by univariate analysis included radiation therapy dose, chemotherapy, diameter of tumor, number of tumor, site of tumor, radiotherapy-time, KPS. According to multivariate analysis the independent prognostic factors were radiotherapy dose and chemotherapy. [ Conclusion] Threedimensional conformal radiotherapy is an effective treatment of liver metastasis. Dose of radiation and chemotherapy are the independent prognostic factors of those patients.

关 键 词：肝转移瘤 立体定向适形放疗 多因素分析 

分 类 号：R735.7[医药卫生—肿瘤]