CXCR4在复发性膀胱癌中的表达及意义  

Expression and significance of CXCR4 in palindromic bladder cancer

作　　者：朱志强[1] 文建国[1] 索振河[2] 樊长辉[1] 王道协[1] 郑湘予[1] 

机构地区：[1]郑州大学第一附属医院,河南郑州450052 [2]挪威奥斯陆大学国家医院

出　　处：《山东医药》2007年第27期55-56,共2页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(30571931)

摘　　要：目的探讨CXCR4在复发性膀胱癌中的表达及临床意义。方法通过免疫组化方法检测16例1 a内复发的膀胱癌及24例1 a内未复发的膀胱癌中CXCR4的表达,并比较1 a内复发的快慢与CXCR4的表达的关系。结果与1 a内未复发的膀胱癌相比,1 a内复发的膀胱癌表达较高水平的CXCR4,但CXCR4的高表达与1 a内复发的快慢无关。结论CXCR4在易复发的膀胱癌中有较高表达,但与复发的快慢不呈现线性相关。[ Objective ] To investigate the expression and significance of CXCR4 in palindromic bladder cancer. [ Methods] Immunohistochemistry was performed to detect the expression of CXCR4 on 16 bladder cancer specimens recurring in 1 year and 24 specimens nulli-palindromia in l year. [ Result] Specimens recurring in l year showed higher positive staining of CXCR4 protein than those cases nulli-palindromia in 1 year. CXCR4 express/on was independent of early palindromic bladder cancer within 1 year. [ Conclusion] Up-regulated expression of CXCR4 was detected in palindromic bladder cancer but it has non-colinearity with early palindromic bladder cancer .

关 键 词：膀胱肿瘤 CXCR4 复发 

分 类 号：R737.14[医药卫生—肿瘤]