脂质体阿霉素在肿瘤热化疗中的研究进展  

Pegylated liposomal doxorubicin in tumor thermo-chemotherapy on neoplasms

作　　者：张振华（综述）[1] 吴敬波（审校）[1] 

机构地区：[1]泸州医学院附属医院肿瘤科,646000

出　　处：《国际肿瘤学杂志》2007年第10期744-746,共3页Journal of International Oncology

摘　　要：体内外研究表明，脂质体阿霉素在肿瘤热化疗研究方面，联合热疗疗效明显优于单独热疗或单药脂质体阿霉素治疗，其作用机制可能是热疗直接引起阿霉素从脂质体中释放，增加加热区域肿瘤组织的微循环渗透压，从而增加了肿瘤细胞对药物的生物利用度，发挥协同增加抗肿瘤作用。临床研究表明，联合热化疗在难治性或复发的卵巢癌、晚期乳腺癌、恶性软组织肉瘤及肝癌等晚期恶性肿瘤疗效较好。In vitro and in vivo studies show the effect of pegylated liposomal doxorubicin combined with hyperthennia superior to pegylated liposomal doxorubicin or hyperthennia alone. The mechanism is that local hyperthennia causes doxorubicin releasing form liposome, and permeability of the tumor microvasculature is increased, resulting in increased usage of doxorubicin in tumor cells, then a synergistic action is achieved. In most clinical studies,the thenno-ehemotherapy is effective in refractory or recurrent ovarian cancer, advanced breast cancer, advanced soft-tissue sarcoma and advanced hepatocellular carcinoma.

关 键 词：多柔比星 脂质体 化学疗法 辅助 高温 诱发 肿瘤 

分 类 号：R730.58[医药卫生—肿瘤]