Studies on molecular interactions between puerarin and PC liposomes  

作　　者：XI JuQun GUO Rong 

机构地区：[1]School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China

出　　处：《Chinese Science Bulletin》2007年第19期2612-2617,共6页

基　　金：the National Natural Science Foundation of China (Grant No. 20633010)

摘　　要：Fluorescence emission spectra, FTIR spectra, zeta potential measurements, and ab initio quantum calculation are used to study the interaction between puerarin and membranes composed of egg phosphatidylcholine (PC) liposome. The hydrophobic interactions cause the puerarin molecule to partition into lipid bilayers with its B-ring, and favor the displacement of acid-base equilibrium of puerarin towards the base form. Due to the hydrogen bond formation between the puerarin hydroxyl groups and polar groups of PC molecules on the water/membrane interface, puerarin can easily intercalate into the organized structure of phospholipids and modulate the membrane function. Our results reveal that the liposome membrane integrity is significantly higher compared with that of empty liposome.Fluorescence emission spectra, FTIR spectra, zeta potential measurements, and ab initio quantum calculation are used to study the interaction between puerarin and membranes composed of egg phosphatidylcholine （PC） liposome, The hydrophobic interactions cause the puerarin molecule to par- tition into lipid bilayers with its B-ring, and favor the displacement of acid-base equilibrium of puerarin towards the base form, Due to the hydrogen bond formation between the puerarin hydroxyl groups and polar groups of PC molecules on the water/membrane interface, puerarin can easily intercalate into the organized structure of phospholipids and modulate the membrane function, Our results reveal that the liposome membrane integrity is significantly higher compared with that of empty liposome,

关 键 词：葛根黄素 卵磷脂 脂质体 药物包装 

分 类 号：TQ460.69[化学工程—制药化工]