转化生长因子β_1基因产物在人非小细胞肺癌中的表达研究  

A Study on the Expressional Products of Transforming Growth Factor Beta 1 in Human Non small Cell Lung Cancer

作　　者：许军涛[1] 王允[1] 侯梅[1] 张尚福[1] 秦虹 伍伫[1] 成娘[1] 周清华[1] 

机构地区：[1]华西医科大学附属第一医院胸心外科

出　　处：《中国胸心血管外科临床杂志》1997年第2期76-79,共4页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

摘　　要：目的探讨转化生长因子β１基因表达产物在人非小细胞肺癌中的表达水平及其临床意义。方法采用免疫组织化学方法对７３例人非小细胞肺癌组织中转化生长因子β１基因表达蛋白水平进行了研究。结果转化生长因子β１基因表达水平与肺癌的病期、组织学类型、细胞分化程度，以及肺癌转移有密切关系。转化生长因子β１基因表达水平在腺癌明显高于鳞癌和腺鳞癌，低分化癌明显低于中－高分化癌，Ⅲ、Ⅳ期癌明显低于Ⅰ、Ⅱ期癌，转移癌明显低于原发癌，有淋巴结转移的原发癌明显低于无淋巴结转移的原发癌（Ｐ＜０．０１或Ｐ＜０．０５）。结论转化生长因子β１基因参与调控肺癌的发生、发展和转移过程。Objective To explore the expressional level of the transforming growth factor beta 1 gene products and it's clinical importance in non small cell lung cancer. Methods The expressional level of transforming growth factor beta 1 protein was detected in 73 human non small cell lung cancer samples by immunohistochemistry. Results The results showed that the expressional level of transforming growth factor beta 1 protein was closely related to stages of cancer, type of histological classification, degree of cell differentiation and presence of lymph node metastasis. The protein expression level of transforming growth factor beta 1 in adenocarcinoma in significantly higher than that in squamous cell carcinoma and adenosquamous carcinoma. The protein level in poor differentiated cancer is significantly lower than that in well and moderately differentiated cancer, in stage Ⅲ and Ⅳ than that in stage Ⅰ and Ⅱ, in metastasis cancer than that in primary cancer, and in the primary cancer with lymph node metastasis than that in primary tumor without lymph node metastasis ( P <0.01 or P <0.05). Conclusion The results suggest that transforming growth factor beta 1 gene may involve the histogenesis, development and metastasis of lung cancer.

关 键 词：转化生长因子 Β1基因 非小细胞肺癌 肺肿瘤 

分 类 号：R734.202[医药卫生—肿瘤]