氟哌啶醇治疗后精神分裂症脑脊液CCK-8变化  

Change of cerebrospinal fluid level of immunoreactive cholecystokinin octapeptide(CCK-8)after six week treatment with haloperidol in schizophrenic patients

作　　者：孟凡强[1,2,3] 林凯[1,2,3] 王善慧 王祖新[1,2,3] 沈上 周岩 韩济生[1,2,3] 

机构地区：[1]北京医科大学精神卫生研究所 [2]解放军总参保健科 [3]北京医科大学神经生理研究中心

出　　处：《临床精神医学杂志》1997年第3期137-140,共4页Journal of Clinical Psychiatry

摘　　要：应用放射免疫法测定８例精神分裂症患者及其性别、年龄配对的正常人脑脊液（ＣＳＦ）８肽胆囊收缩素（ＣＣＫ—８）的免疫反应活性，观察了患者在氟哌啶醇治疗６周后ＣＳＦ中ＣＣＫ—８免疫反应活性的变化，以及他们治疗前后２４小时尿ＭＨＰＧ排泄量的变化。结果发现，患者基础状态下ＣＳＦＣＣＫ—８显著低于与其性别、年龄配对的正常人。经６周氟哌啶醇治疗后患者ＣＳＦＣＣＫ—８显著增高，接近正常对照组。治疗前ＣＳＦＣＣＫ—８与ＳＡＮＳ评分呈显著负相关，而与ＳＡＰＳ评分呈显著正相关。正常对照组及患者治疗后的ＣＳＦＣＣＫ—８免疫反应活性与年龄皆呈高度正相关。Objective:To study the relationship between change of CSF level of cholecystokinin octapeptide after haloperidol treatment and mental state in schizophrenic patients.Method:CSF level of immunoreactive CCK-8 was measured with radioimmunoassay before and after six week treatment with haloperidol in eight schizophrenic inpatients.24 hour urine was also collected for 3-methoxy-4-hydroxyphenylglycol sulfate(MHPG).Similar blood and urine samples were also collected for matched controls.Mental state of patients was monitored with Scale for the Assessment of Negative Symptoms (SANS) and Positive Symptoms (SAPS).Results:The baseline CSF CCK-8 was significantly reduced in schizophrenic patients than controls and was raised after six week treatment with haloperidol to near normal level.Patients baseline CSF CCK-8 was negatively correlated with the negative symptoms and positively correlated with the positive symptoms.A high positive correlation was also found between age and CSF CCK-8 level in both control and patient group after haloperidol treatment.Discussion:Cerebrospinal level of cholecystokinin octapeptide could be good biolgical marker for diagnosis and treatment response of schizophrenia.

关 键 词：精神分裂症 脑脊液 8肽胆囊收缩素 氟哌啶醇 

分 类 号：R749.305[医药卫生—神经病学与精神病学] R971.4[医药卫生—临床医学]