Effects of K. Lysolecithin on Blood Levels of Monoamines in Mice  

作　　者：Yuka Itokwa Aki Kozu Takashi Nakamura Takashi Masubuchi Masami Oshima Kwang-Ho Cho Jung-Sook Choi Toshihiro Miura Torao Ishida Yeunhwa Gu 

机构地区：[1]Suzuka Univercity of Medical Science, Graduate School of Health Science [2]Society of Preventive and Alternative Medicine [3]Department of Radiological Science, Catholic University of Deagu, College of Health Science [4]Gyeongdo Provincial College

出　　处：《Journal of Traditional Chinese Medicine》2007年第3期212-219,共8页中医杂志（英文版）

摘　　要：In this research, Lysolecithin-a substance made with 100% natural ingredients - was given to ICR mice as medication to measure its periodic effect on the noradrenalin (NA), dopamine (DA), and serotonin (5-HT) levels of the brain. Both ICR and SAM mice were separated into two groups - control group and Lysolecithin (K. Lysolecithin: hydrolytic lysolecithin) medicated group, and given 1-week preparation period. The K. Lysolecithin group was given 500mg/kg of K. Lysolecithin at 0.2mL per dosage for 4 weeks, and the control group was given the same amount of dosage of water during the same period. NA, DA and 5-HT concentrations were measured from the blood before medication and 8 weeks / 12 weeks / 16 weeks after the first medication. For the SAM mice, 8 weeks after they were medicated with K .Lysolecithin, Morris Water Maze Test was conducted for 7 consecutive days and then the concentrations were measured by drawing blood from the heart. The K. Lysolecithin medicated group showed a tendency to have a statistically significant higher concentrations of 5-HT and NA in the blood. Also, periodic examination showed that the monoamine levels were highest in the 12th week and declined thereafter.In this research, Lysolecithin - a substance made with 100% natural ingredients - was given to ICR mice as medication to measure its periodic effect on the noradrenalin （NA）, dopamine （DA）, and serotonin （5-HT） levels of the brain. Both ICR and SAM mice were separated into two groups - control group and Lysolecithin （K. Lysolecithin： hydrolytic lysolecithin） medicated group, and given 1-week preparation period. The K. Lysolecithin group was given 500mg/kg of K. Lysolecithin at 0.2mL per dosage for 4 weeks, and the control group was given the same amount of dosage of water during the same period. NA, DA and 5-HT concentrations were measured from the blood before medication and 8 weeks / 12 weeks / 16 weeks after the first medication. For the SAM mice, 8 weeks after they were medicated with K .Lysolecithin, Morris Water Maze Test was conducted for 7 consecutive days and then the concentrations were measured by drawing blood from the heart. The K. Lysolecithin medicated group showed a tendency to have a statistically significant higher concentrations of 5-HT and NA in the blood. Also, periodic examination showed that the monoamine levels were highest in the 12th week and declined thereafter.

关 键 词：K. Lysolecithin SEROTONIN NORADRENALIN DOPAMINE Alzheimer＇s Syndrome 

分 类 号：R285.5[医药卫生—中药学]