维持性血液透析患者血浆抗坏血酸的变化及意义  

The Changes of Plasma Antiscorbic Acid in Patients with Maintainenance Hemodialysis and Its Significance

作　　者：金立民[1] 刘国平[1] 黄九香[1] 

机构地区：[1]内蒙古自治区医院肾内科,内蒙古呼和浩特010017

出　　处：《内蒙古医学杂志》2007年第8期926-928,共3页Inner Mongolia Medical Journal

摘　　要：目的:探讨维持性血液透析(maintenance hemodialysis,MHD)患者血浆抗坏血酸(ascorbic acid,AA)、脱氢型抗坏血酸(dehydroascorbic acid,DHAA)及血浆总抗坏血酸(total ascorbic acid,TAA)水平的变化及意义。方法:将研究对象分为两组,MHD组为18例维持性血液透析患者;对照组为19例健康志愿者。血浆总抗坏血酸(Total Ascorbic Acid,TAA)和DHAA采用高效液相色谱法(high performance liquid chro-matography,HPLC)结合电化学检测器测定。结果:MHD组与健康对照组之间性别相匹配,年龄无统计学差异(t=0.372,P>0.05)。MHD患者血浆AA水平低于健康人群(t=2.291,P<0.05);MHD患者血浆DHAA水平明显高于健康人群(t′=4.253,P<0.001);而MHD患者血浆TAA水平与健康人群相比无显著性差异(t=1.481,P>0.05);MHD患者血浆DHAA/TAA水平明显高于健康人群(t′=4.193,P<0.01)。结论:维持性血液透析患者血浆抗坏血酸水平下降,血浆脱氢型抗坏血酸水平及脱氢型抗坏血酸与血浆总抗坏血酸比值明显升高,而血浆总抗坏血酸水平却无明显变化。为发挥抗坏血酸抗氧化保护作用而恰当的为维持性血液透析患者补充抗坏血酸仍需进一步研究。　Objective：To investigate the changes of plasma antiscorbic acid（AA）, dehydroascorbic acid（DHAA） and total antiscorbic acid（TAA） in patients with maintenance hemodialysis（MHD） and its significances.Methods： 18 patients with MHD were selected as MHD group and 19 normals as control group.The levels of TAA and DHAA were detected by high performance liquid chromatography（HPLC） combined with electrochemical detector.Results： The sex was matched and the age had no difference between MHD group and control group（t=0.372,P〉0.05）.The level of plasma AA in MHD group was lower than that in control group（t=2.291,P〈0.05）,that of DHAA and DHAA/TAA was higher than those in control group（t′=4.252,P〈0.001;t′=4.193,P〈0.01）,but the level of TAA showed no difference（t=1.481,p〉0.05）.Conclusion： The level of AA decreases and that of DHAA and DHAA/TAA increases,but the level of TAA has no changes in patients with MHD.Proper supply of AA for patients with MHD should be furtherly researched.

关 键 词：维持性血液透析 抗坏血酸 脱氢型抗坏血酸 氧化应激 

分 类 号：R692.5[医药卫生—泌尿科学]