大剂量阿糖胞苷治疗急性白血病的临床观察  

Clinical Observation of Large Dose of Arabinosylcytosin in Treatment of Acute Leukemia

作　　者：刘建平[1] 郄丽萍[1] 王向文[1] 

机构地区：[1]内蒙古自治区医院儿科,内蒙古呼和浩特010017

出　　处：《内蒙古医学杂志》2007年第8期942-943,共2页Inner Mongolia Medical Journal

摘　　要：目的:探讨以大剂量阿糖胞苷(HD-AC)用于急性白血病完全缓解(CR)后巩固强化治疗和难治性复发性髓系白血病的疗效及副作用。方法:HD-AC治疗8例急性髓系白血病(AML)和2例复发性髓系白血病,每次2.0g/m2,q.12h,6次为1个疗程,化疗中使用G-CSF。结果:以HD-AC为主联合化疗AMI缓解6例,复发者缓解1例,缓解率70%。最主要的副作用是骨髓严重抑制和感染。结论:以HD-AC为主的联合化疗方案可用于急性白血病的强化治疗,对降低复发、提高无病生存率有积极的意义。　Objective：To evaluate the curative effectiveness and side effect of large dose of arabinosylcytosin（Ara-C） during intensification therapy for complete recovery（CR） of acute leukemia or for recurrent marrow leukemia.Methods： In 8 cases of acute marrow leukemia（AML） and 2 cases of recurrent marrow leukemia,HK-AC were administrated in dose of 2.0g every m^2,every 12 hours for a period up to 6 times.G-CSF was given during chemotherapy.Results： 6 cases of AML and 1 recurrent one relieved with therapy of large dose of Ara-C.The rate of relief was 70%.The main side effects had serious marrow inhibition and infection.Conclusion： Combined chemotherapy including main Ara-C should be applied in intensification therapy for acute leukemia.This methods is significant in reducing recurrent and improving survival rate.

关 键 词：大剂量阿糖胞苷 急性白血病 强化治疗 

分 类 号：R733.71[医药卫生—肿瘤]