Survivin蛋白在舌鳞癌中的表达及意义  

Expression of Survivin in Tongue Carcinoma and Clinical Significance

作　　者：刘善廷[1] 魏林[1] 秦建武[1] 赵军方[2] 

机构地区：[1]河南省肿瘤医院头颈外科,郑州市450008 [2]郑州大学第一附属医院口腔科,郑州市450052

出　　处：《医药论坛杂志》2007年第17期4-5,共2页Journal of Medical Forum

基　　金：河南省省属院所资金项目(编号:0441130405);河南省科技攻关项目(编号:0424410021)

摘　　要：目的研究Survivin蛋白在舌鳞癌中的表达及其与各临床病理因素的关系。方法应用免疫细胞化学法检测舌癌Tca-8113细胞株中Survivin蛋白的表达;应用免疫组织化学法检测Survivin蛋白在60例舌鳞癌组织中的表达情况。结果Survivin在舌癌Tca-8113细胞株中阳性表达,在舌鳞癌中阳性表达率为65.0%(39/60),其阳性表达在淋巴结转移特点、病理分化等方面差异有显著性(P<0.05)。结论Survivin基因与舌鳞癌的自然发展过程有关,可能成为舌癌新的诊断标志及基因治疗的靶点。Objective To study the expression of Survivin protein in tongue carcinoma and its significance. Methods The expression of Survivin protein was detected in Tca- 8113 cell line and 61） cases of tongue carcinoma tissues by immunohistochemistry. Results Survivin protein was positive in Tca- 8113, the positive rate of Survivin protein was 65.0% （39/60） in tongue carcinoma tissues and the positive rate was correlated with lymph node metastasis and histological grade （P 〈 0.05 ） . Conclusion Survivin gene is involved in the development of tongue carcinoma and probably become a new biomarker and target of gene therapy.

关 键 词：SURVIVIN蛋白 舌鳞癌 病理 

分 类 号：R739.86[医药卫生—肿瘤]