口腔粘膜癌前病变C-erbB-2蛋白产物检测  

Determination of C-erbB-2 Oncoprotein in Precancerous Lesions of Oral Mucosa

作　　者：龙彦[1] 凌涤生[1] 王力[1] 

机构地区：[1]山东医科大学口腔医院,250012

出　　处：《现代口腔医学杂志》1997年第2期87-89,共3页Journal of Modern Stomatology

摘　　要：采用免疫组化染色和图像分析技术,检测了9例口腔上皮单纯增生,49例不同程度异常增生和21例鳞状细胞癌中C-erbB-2蛋白产物表达.结果显示.单纯增生中癌基因蛋白无明显异常,轻度异常增生中阳性表达略有增加.随着异常增生程度加重,C-erbB-2阳性细胞明显增多,染色程度显著增强.所有鳞状细胞癌标本均出现C-erbB-2蛋白过量表达.由此提示C-erbB-癌基因与口腔鳞状细胞癌的发生发展过程有关,其蛋白产物检测可作为评估口腔粘膜癌前病变恶变风险的一项有用指标.Immunohistochemical staining and computer-assistant image analysis were used to detect C-erbB-2 oncoprotein in 9 cases of epithelial hyperplasia, 49 cases of epithelial dysplasia and 21 squamous cell carcinomas of the oral mucosa. There was almost no C-erbB-2 expression in cases of hyperplasia, but a low positive rate was found in cases of mild dysplasia. Both positive rate and staining intensity were dramatically increasing in cases of moderate and severe dysplasia. All squamous cell carcinomas overexpressed C-erbB-2 oncoprotein. This result indicated that C-erbB-2 expression was correlated with carcinogenesis of oral squamous cell carcinoma. It is useful to detect C-erbB-2 oncoprotein for assessing the malignant potential of oral epithelial cells.

关 键 词：癌基因 癌前病变 口腔粘膜肿瘤 

分 类 号：R739.85[医药卫生—肿瘤]