动脉插管化疗配合膀胱灌注治疗复发性、多发性、表浅性膀胱癌  

Using Arterial Intubation Chemotherapy plus Perfusion of Bladder to Cure Recurrent Multiple Superficial Cancer of Bladder

作　　者：陈辉[1] 崔岩[1] 乔忠杰[1] 徐万海[1] 赵丕显[1] 

机构地区：[1]哈尔滨医科大学附属第三医院泌尿外科,哈尔滨150040

出　　处：《现代生物医学进展》2007年第10期1528-1529,共2页Progress in Modern Biomedicine

基　　金：黑龙江省自然科学基金资助(1999C19-6)

摘　　要：目的:探讨腹壁下动脉插管化疗(inferior-epigastric artery chemotherapy,IAC)配合吡柔比星(THP)膀胱灌注治疗复发性、多发性和表浅性膀胱癌的疗效。方法:对12例复发性、多发性和表浅性膀胱移行细胞癌患者术后行腹壁下动脉插管化疗3个疗程后,开始行吡柔比星膀胱灌注,每次30 mg,每周1次共12次,以后每2周1次共6次,以后每月1次共6次,第二年重复,第三年每月一次。定期膀胱镜检查,进行随访。结果:12例复发性、多发性、浅表性膀胱移行细胞癌患者,术后随访时间24-48个月,肿瘤复发1例,复发率8.3%。不良反应主要为术后小膀胱,尿路刺激症状和尿常规异常。结论:腹壁下动脉插管化疗配合吡柔比星膀胱灌注治疗复发性、多发性和表浅性膀胱癌的效果明确,疗效满意,患者耐受性好,值得临床推广应用。Objective： To investigate the therapeutic effect of arteria epigastrica inferior intubation chemotherapy plus perfusion of bladder for recurrent multiple superficial cancer of bladder. Methods： A total of 12 patients, who were suffered from recurrent multiple superficial bladder cancer, were selected. They were given arterial intubation chemotherapy for 3 courses after operation, then, with perfusion of bladder at a dose of 30 mg first once a week for 12 times, second once every two weeks for 6 times, lastly once a month for 6 times. The course was repeated in the next year,and once a month in the 3rd year. During the courses, follow-up routinely cystoscope examination was done. Results： All the 12 patients were followed up for 24-48 months after operation. Only 1 patient recurred and the recurrence rate was 8.3%. The main side effects were bladder contracture, urethral irritation and urinalysis abnormality. Conclusion： The therapeutic effect of arteria epigastrica inferior intubation chemotherapy plus perfusion of bladder for recurrent multiple superficial cancer of bladder is satisfactory,which is worth spreading in the clinical application.

关 键 词：腹壁下动脉插管化疗 吡柔比星 复发多发表浅性膀胱癌 膀胱灌注 

分 类 号：R737.14[医药卫生—肿瘤]