持续缓慢静脉输注三氧化二砷治疗急性早幼粒细胞白血病的临床护理效应  

Clinical Nursing Effects of Acute Promyelocytic Leukemia Treated with Arsenic Trioxide by Persistence Slowing-Intravenous Infusion

作　　者：王艳萍[1] 钟涛[1] 

机构地区：[1]哈尔滨医科大学第一附属医院,哈尔滨150001

出　　处：《现代生物医学进展》2007年第10期1536-1538,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金<持续缓慢静脉输注三氧化二砷治疗急性早幼粒细胞白血病>(30370507)

摘　　要：目的:观察持续缓慢输注三氧化二砷(As_2O_3)治疗急性早幼粒细胞白血病(APL)病人的临床护理效应。方法:对196例急性早幼粒细胞白血病患者(APL)给予持续缓慢静脉输注As_2O_3治疗,每例患者As_2O_3日治疗总量按0.16mg/kg计算,As_2O_3注射液10毫克(10 mg/支),加入5%葡萄糖500毫升(或生理盐水500毫升)静脉滴注,8-10滴/分钟,每次滴注约18-21小时,连续用药28-50天,至完全缓解(CR)。同时,注重心理护理,加强输液管理,在用药过程中严密观察药物的毒副作用和对不良反应的及时对症护理等措施。结果:177例病人完全缓解(CR),完全缓解率达90.3%。结论:应用持续缓慢静脉输注As_2O_3治疗APL,实施积极有效的护理措施是取得显著疗效的重要环节。Objective： To observe and nurse acute promyelocytic leukemia （APL） treated with arsenic trioxide by persistence slowing-intravenous infusion. Methods： 196 APL cases were treated with As2O3 of persistence slowing-intravenous infusion, For every patient, we emphasized on mental nursing and infusion administration and adopted a measure of symptomatic nursing when adverse reaction occurred. Results： 177 cases reached complete remission and the rate was 90,3%, Conclusion： It suggested that persistence slowing-intravenous infusion with supportive treatment and nursing could raise therapeutic effect significantly.

关 键 词：持续缓慢静脉输注 三氧化二砷 急性早幼粒细胞白血病 护理效应 

分 类 号：R733.71[医药卫生—肿瘤]